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Questions related from Ian J Martins
The early diagnosis of Alzheimer's disease (AD) has become important to the reversal and treatment of neurodegeneration which may be relevant to premature brain aging associated with chronic...
28 October 2024 6,860 1 View
The peripheral sink amyloid beta clearance pathway is defective in diabetes and Alzheimer’s disease. The release of amyloid beta (4 kd) monomers from neurons is associated with the amyloid beta...
14 October 2024 7,015 1 View
Time restricted eating/feeding has become of major interest to the treatment of neuroinflammation in Alzheimer’s disease patients. The effects of time restricted eating/feeding on gut microbiome...
02 October 2024 3,296 0 View
The literature shows that mild cognitive impairment (MCI)-specific mycobiome signatures show that distinct diets modulate the mycobiome in association with Alzheimer’s disease (AD) markers and...
19 August 2024 2,212 0 View
The role of gut microbiota and diet has become a major concern for the health of Alzheimer’s disease (AD) individuals. The literatures shows that the microbiome composition has been linked to...
24 June 2024 9,638 1 View
The literature shows that gut microbiota plays a significant role in the development and progression of liver diseases. Research suggests that a disturbance to the gut microbiome leads to hepatic...
22 May 2024 6,047 2 View
1. Researchers highlight that they are the first to report on the function and applications of the CRISPR–Cas9 system. The authors explain how the CRISPR technology in clinical practice could be...
17 May 2024 7,087 0 View
Biotherapeutics and nutritional biotherapy have become important to reverse global chronic diseases. The role of Indian spices and biotherapeutics in health and chronic disease has become of major...
06 March 2024 9,601 0 View
The anti-aging gene Sirtuin 1 is associated with the reversal of cell senescence and apoptosis with relevance to many organs and tissues. Sirtuin 1 repression is linked to the global chronic...
28 February 2024 5,836 0 View
The binding of Sirtuin 1 to PCSK9 is important to reduce PCSK9 levels and reduce low density lipoprotein cholesterol. The role of increased PCSK9 levels with low Sirtuin 1 levels may determine the...
09 August 2023 2,397 0 View
The anti-aging protein Sirtuin 1 is critical to the anti-aging process and the prevention of obesity, diabetes, NAFLD and neurodegenerative diseases. Low plasma Sirtuin 1 levels are linked to the...
03 July 2023 8,774 0 View
Therapeutics such as probiotics exert a beneficial effect on host gut microbiota after consumption and may be capable to prevent several diseases such as Alzheimer’s disease. Fermented dairy...
23 May 2023 1,611 1 View
RELEVANT REFERENCES: 1. Shanshal M, Ahmed HS. COVID-19 and Herpes Simplex Virus Infection: A Cross-Sectional Study. Cureus. 2021 Sep 16;13(9):e18022. 2. Chen, J, Song, J, Dai, L, Post, SR, Qin, Z....
08 May 2023 1,751 0 View
The literature indicates that low-dosage aspirin administration as an anti-aging agent has evolved from the multitude of properties associated with aspirin to prevent the cellular and functional...
10 March 2023 3,748 0 View
Sirtuin 1 has been shown to deacetylate FOXO3 and FOXO4 and Sirtuin 1 has been involved in deacetylation of histone 3 (H3) and histone 4 (H4). Researchers have shown that epigenetically the...
01 February 2023 4,154 0 View
The binding of Sirtuin 1 to PCSK9 is important to reduce PCSK9 levels and reduce low density lipoprotein cholesterol. In man low Sirtuin 1 has been shown to be associated with cardiovascular...
20 January 2023 7,789 0 View
Bacterial lipopolysaccharides (LPS) released from gram negative bacteria are toxic and have been shown to induce dyslipidemia, diabetes and neurodegenerative diseases. LPS has been linked to...
02 December 2022 1,277 0 View
The literature indicates that yoghurt contains live bacteria that have major effects on gut dysbiosis, metabolism, insulin resistance and neurodegeneration. Gram negative bacteria release...
24 November 2022 4,321 1 View
The literature reports that COVID-19 vaccination has altered the course of the pandemic and has saved millions of lives. The inadequate access to vaccines in the developing world and low-income...
17 October 2022 2,610 7 View
The purposes of drug therapy is to help with the treatment or even cure of a disease process. When prescribing drugs for the individual patient, guidelines, formularies and other prescribing aids...
04 October 2022 5,932 0 View
The relevance of the Microbiota-Gut-Brain axis to Alzheimer’s and neurodegenerative diseases needs extensive analysis. The various articles indicate that there are various questions with relevance...
03 August 2022 3,986 3 View
The importance of circadian alignment of feeding on longevity under calorie restriction has never been shown and experiments conducted in mice by Takahashi has studied the contributions of feeding...
16 June 2022 5,078 0 View
The literature shows that major depression, bipolar disorder, schizophrenia, and obsessive compulsive disorder are the most common mental disorders in the developing and developed world. Studies...
29 October 2021 7,142 0 View
Heroin abusers are associated with accelerated aging and neurodegenerative disease. The cellular effects of heroin is possibly linked to mitochondrial apoptosis. The risk of uncontrolled heroin...
04 October 2021 5,893 2 View
The authors show that the hepatic expression of the hepatic specific humanised APP gene (HSHA) in 6, 12, 18 and 24 month mice that leads to the synthesis of human amyloid beta that results in...
24 September 2021 7,856 0 View
Plasma protein controls of human serum are important to decide on the protein concentrations of the control plasma/serum. The control plasma/serum should contain plasma proteins within the...
10 September 2021 7,654 3 View
RELEVANT REFERENCES: Polypharmacy (Antipsy: antipsychotic, antidepress: antidepressant, cholesterol lowering drugs, aspirin, etc) 1. Scott T. Chiesa and Marietta Charakida. High-Density...
29 April 2021 7,945 5 View
Can the potential of plasma LIPIDMICS improve the diagnosis and understanding of metabolic changes in various neurodegenerative diseases (Parkinson’s disease, Huntington’s disease, Mutiple...
09 November 2020 7,569 1 View
The metabolic syndrome is characterized by dyslipidemia and hypertension in obese individuals. Lipoprotein subfractionation of plasma from obese individuals indicate the presence of large very low...
08 June 2020 3,136 2 View
Nutritional science has provided functional foods with the required amounts of natural antioxidants, vitamins, fats, proteins, polyphenols, carbohydrates, and other components required to maintain...
04 June 2020 7,696 1 View
Ketogenic diets play an important role in histone acetylation and deacetylation by inhibition of histone deacetylases (HDAC). Ketone bodies have been shown to inhibit HDAC 1, 3 and 4 at various...
01 April 2020 5,540 5 View
Butyric acid regulates gene expression by inhibiting histone deacetylases (HDACs). Butyrate induces growth arrest in a variety of normal cell types and senescence-like cancer cells by inhibiting...
16 January 2020 6,558 3 View
The interest in the peptide apelin that has been identified as an anti-aging factor has escalated and its inactivation leads to inactivation of the anti-aging gene Sirtuin 1. Accelerated aging and...
15 January 2020 1,870 0 View
RELEVANT REFERENCES: 1. Indian Spices and Biotherapeutics in Health and Chronic Disease. Health, 10, 374-380. 2. Indian Spices and Insulin Therapy in Diabetes and Neurodegenerative Diseases. J...
09 October 2019 9,448 6 View
Nutritional interventions to reverse Type 2 diabetes has accelerated with relevance to the global Type 2 diabetes epidemic. The recent interest in Type 3 diabetes has now linked the reversal of...
26 June 2019 2,757 4 View
Interests in Biomarker Research has escalated with relevance to mitochondrial survival and global organ disease in diabetes and Alzheimer’s disease. Biomarker Research is expected to cost approx...
25 June 2019 5,504 2 View
PLEASE SEE ATTACHED FIGURE ENTITLED: DYNAMIIC PHOSPHOLIPID METABOLISM IS CONTROLLED BY SIRTUIN 1. RELEVANT REFERENCES: 1. I.J.Martins and T.G. Redgrave. 1992. The effects of Insulin-deficiency...
07 June 2019 3,793 0 View
REFERENCE 1: Sanjay Kalra, Jubbin Jagan Jacob, and Yashdeep Gupta. Newer antidiabetic drugs and calorie restriction mimicry. Indian J Endocrinol Metab. 2016 Jan-Feb; 20(1): 142–146....
18 April 2019 614 1 View
18 April 2019 9,311 1 View
RELEVANT REFERENCES: 1. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions. EC Pharmacology and Toxicology 6.4 (2018): 209-215....
03 April 2019 3,819 0 View
RELEVANT REFERENCES: 1. Antibiotic use and Nuclear Receptor Inactivation linked to Mitophagy in Diabetes and Chronic Diseases. Journal of Diabetes and Clinical Studies. 2018;2(1):1-3. 2. Sirtuin...
19 March 2019 8,999 0 View
REFERENCES: 1. Antibiotic Use and Nuclear Receptor Inactivation Linked to Mitophagy in Diabetes and Chronic Diseases. Journal of Diabetes and Clinical Studies. 2018,2 (1);1-3. 2. Sirtuin 1, a...
19 November 2018 5,611 1 View
RELEVANT REFERENCES: 1. Martins IJ. Advances in Aging and Health Research. Scientific Research Publishing, Inc. ISBN: 978-1-61896-569-1 2. Martins IJ. Scientific Nutritional Health and Global...
12 September 2018 2,765 1 View
ABSTRACT General anesthesia, Sedation, Regional anesthesia and local anesthesia (doses of one or more drugs) and the types of drugs used include general anesthetics, hypnotics, sedatives,...
12 September 2018 2,027 0 View
RELEVANT REFERENCES: PRESENTATION: Transcriptional Dysregulation of Sirtuin 1 is Relevant to Diabetes and Global Chronic Disease Global Experts Meeting On Diabetes, Hypertension & Metabolic...
30 July 2018 838 0 View
Survival of the species and regulation of heat shock protein (HSP) levels are critical to prevent toxic protein aggregation and mitophagy. Dietary activators, drugs and inhibitors may reverse...
02 July 2018 4,130 0 View
ABSTRACT Genomic medicine treatment of diabetics is critical in the current global diabetes epidemic to prevent the expected diabetes pandemic predicted to occur by the year 2035. The major...
28 May 2018 9,996 1 View
Electroconvulsive therapy (ECT) as an established technique and technology in a variety of psychiatric and neurologic conditions may require reassessment with relevance to memory loss and brain...
17 May 2018 9,919 1 View
The diabetes epidemic has become a major public concern in the developing and developed world. It is expected that by the year 2035 approx. 592 million people are to be affected with diabetes...
21 February 2018 7,057 4 View
Evaluation of diagnostic tests and biomedical data that have promised detection of early disease progression have raised concerns with under-diagnosis of various chronic diseases associated with...
09 February 2018 1,841 0 View
Curcumin is a potent inducer of the heat shock response with complete interference of the heat shock gene Sirtuin 1 (Sirt 1) regulation of heat shock protein 70 (HSP 70). Sirt 1 is the heat shock...
07 February 2018 1,090 2 View
Nutritional genomics allows the use of nutrition research to determine nutritional interventions that enables gene expression that improves the health and wellbeing of individuals in the...
26 January 2018 9,056 1 View
The health promoting benefits and protective role of Indian spices has been reported in chronic disease with their role as a antimicrobial agent important to the prevention of NAFLD, heart...
19 January 2018 5,339 1 View
The consumption of INDIAN SPICES (grams/day) over many years (30 years) may accumulate in the brain. The brain may accumulate INDIAN SPICES but the spices may not be cleared. The liver may be one...
21 December 2017 7,504 11 View
Delayed hepatic caffeine metabolism in NAFLD and increased caffeine transport to the brain with aging-induced mitophagy in neurons is associated with the induction of Type 3 diabetes and...
15 November 2017 6,240 2 View
CERTIFICATE FOR EXCEPTIONAL EFFORT Please see Presentation below entitled " Drug-Drug Interactions with Relevance to Drug Induced Mitochondrial Toxicity and Accelerated Global Chronic...
14 November 2017 3,253 4 View
REFERENCES 1. Apelin and Sirtuin 1 Dysregulation induce Endocrine and Metabolic Disorders in Chronic Disease. 1(1). GJEM.000501. 2017. 2. The Future of Genomic Medicine Involves the Maintenance of...
27 September 2017 9,377 1 View
Please see attached file PRESENTATION IBC-2017 Nutrition Therapy Regulates Caffeine Metabolismwith Relevance to NAFLD and Induction of Type 3 Diabetes.XIAN, CHINA ONLINE REFERENCE: Nutrition...
03 May 2017 7,367 0 View
Caffeine Consumption and Induction of Obesity in the Developed World. Ann Obes Disord. 2017; 2(1): 1018.
26 January 2017 6,389 1 View
REFERENCE: Early Diagnosis of Neuron Mitochondrial Dysfunction May Reverse Global Metabolic and Neurodegenerative Disease. Global Journal of Medical Research: A Neurology and Nervous System Volume...
17 January 2017 2,162 2 View
Magnesium is important to lower cholesterol and maintain the peripheral clearance to toxic amyloid beta. Active lifestyles with exercise reduce magnesium levels with increase risk for Type 3...
15 July 2016 6,399 5 View
The major risk of overconsumption of a high fibre diet will lead to excessive intake of phytosterols that lead to neurodegeneration. Diets that are high in fibre in the developing world may also...
15 July 2016 1,977 3 View
Unhealthy diets that contain bacterial lipopolysaccharides (LPS) promote amyloid beta aggregation and healthy diets in the developing world are encouraged to reduce the toxic amyloid beta speices...
15 July 2016 2,311 4 View
Overeating can be controlled by the food restriction procedures that may prevent the consumption of various xenobiotics that may disrupt astrocyte-neuron interactions in the hypothalamus that are...
15 July 2016 2,579 9 View
The diets that contain bacterial lipopolysaccharides change cell membranes and delay the clearance of mycotoxins such as patulin and ochratoxin A that enter the brain and lead to neuron apoptosis.
15 July 2016 3,952 2 View
