Ian J Martins

17 Questions 11 Answers 0 Followers

Questions related from Ian J Martins

Does PCSK9 interfere with the Apolipoprotein E and Sirtuin 1 interaction with relevance to the brain cholesterol and amyloid beta clearance?

The binding of Sirtuin 1 to PCSK9 is important to reduce PCSK9 levels and reduce low density lipoprotein cholesterol. The role of increased PCSK9 levels with low Sirtuin 1 levels may determine the...

09 August 2023 2,303 0 View

Do probiotic or prebiotic products need to be tested for gram-negative bacteria and lipopolysaccharides for treatment of Alzheimer’s disease patients?

Therapeutics such as probiotics exert a beneficial effect on host gut microbiota after consumption and may be capable to prevent several diseases such as Alzheimer’s disease. Fermented dairy...

23 May 2023 1,507 1 View

Does COVID-19 virus INFECTION and vaccination ACTIVATE and modulate other viral infections?

RELEVANT REFERENCES: 1. Shanshal M, Ahmed HS. COVID-19 and Herpes Simplex Virus Infection: A Cross-Sectional Study. Cureus. 2021 Sep 16;13(9):e18022. 2. Chen, J, Song, J, Dai, L, Post, SR, Qin, Z....

08 May 2023 1,668 0 View

Is a COVID-19 vaccine (COVAX) that is 100% effective, safe without side effects available for global COVID-19 vaccination?

The literature reports that COVID-19 vaccination has altered the course of the pandemic and has saved millions of lives. The inadequate access to vaccines in the developing world and low-income...

17 October 2022 2,493 7 View

Do various CLINICIANS need to monitor Sirtuin 1 gene expression and plasma Sirtuin 1 levels with relevance to various drug therapies in patients?

The purposes of drug therapy is to help with the treatment or even cure of a disease process. When prescribing drugs for the individual patient, guidelines, formularies and other prescribing aids...

04 October 2022 5,862 0 View

Can probiotics (eg yoghurt) activate the anti-aging gene Sirtuin 1 with relevance to the treatment of Alzheimer’s disease?

The relevance of the Microbiota-Gut-Brain axis to Alzheimer’s and neurodegenerative diseases needs extensive analysis. The various articles indicate that there are various questions with relevance...

03 August 2022 3,882 3 View

Are small molecule modulators of CLOCK–BMAL1 Transcription that enhance circadian function in mice determined by Sirtuin 1 activators and inhibitors?

The importance of circadian alignment of feeding on longevity under calorie restriction has never been shown and experiments conducted in mice by Takahashi has studied the contributions of feeding...

16 June 2022 5,003 0 View

Is HEROIN an inhibitor of the anti-aging gene Sirtuin 1?

Heroin abusers are associated with accelerated aging and neurodegenerative disease. The cellular effects of heroin is possibly linked to mitochondrial apoptosis. The risk of uncontrolled heroin...

04 October 2021 5,811 2 View

Can the potential of LIPIDMICS improve the diagnosis and understanding of metabolic changes in various neurodegenerative disease (PD, HD, AD, MS, etc?

Can the potential of plasma LIPIDMICS improve the diagnosis and understanding of metabolic changes in various neurodegenerative diseases (Parkinson’s disease, Huntington’s disease, Mutiple...

09 November 2020 7,360 1 View

Is short chain fatty acid (BUTYRIC ACID) more biologically active and determine the treatment of FUNCTIONAL FOODS in diabetes and Alzheimer’s disease?

Nutritional science has provided functional foods with the required amounts of natural antioxidants, vitamins, fats, proteins, polyphenols, carbohydrates, and other components required to maintain...

04 June 2020 7,505 1 View

Should the HDAC inhibitor butyric acid be re-evaluated in NAFLD or AD relevant to inhibition of the anti-aging gene Sirtuin 1 (histone deacetylase)?

Butyric acid regulates gene expression by inhibiting histone deacetylases (HDACs). Butyrate induces growth arrest in a variety of normal cell types and senescence-like cancer cells by inhibiting...

16 January 2020 6,494 3 View

Is the severity of Type 2 diabetes DETERMINED by Type 3 diabetes?

Nutritional interventions to reverse Type 2 diabetes has accelerated with relevance to the global Type 2 diabetes epidemic. The recent interest in Type 3 diabetes has now linked the reversal of...

26 June 2019 2,507 4 View

Are advances in Anti-Aging Research Therapy to reverse cell death critical to Global Anti-Aging Markets expected to EXCEED $331 billion by 2021?

RELEVANT REFERENCES: 1. Martins IJ. Advances in Aging and Health Research. Scientific Research Publishing, Inc. ISBN: 978-1-61896-569-1 2. Martins IJ. Scientific Nutritional Health and Global...

12 September 2018 2,679 1 View

Does successful insulin therapy involve insulin and Indian spice therapy for diabetes treatment in the global diabetes pandemic?

The diabetes epidemic has become a major public concern in the developing and developed world. It is expected that by the year 2035 approx. 592 million people are to be affected with diabetes...

21 February 2018 6,979 4 View

Is the early detection of global chronic disease related to the induction of autoimmune disease with relevance to endocrinology and metabolism?

REFERENCES 1. Apelin and Sirtuin 1 Dysregulation induce Endocrine and Metabolic Disorders in Chronic Disease. 1(1). GJEM.000501. 2017. 2. The Future of Genomic Medicine Involves the Maintenance of...

27 September 2017 9,185 1 View

How can magnesium therapy reverse diabetes and Alzheimer’s disease?

Magnesium is important to lower cholesterol and maintain the peripheral clearance to toxic amyloid beta. Active lifestyles with exercise reduce magnesium levels with increase risk for Type 3...

15 July 2016 6,192 5 View

Can overconsumption of a high fibre diet lead to liver and brain disease?

The major risk of overconsumption of a high fibre diet will lead to excessive intake of phytosterols that lead to neurodegeneration. Diets that are high in fibre in the developing world may also...

15 July 2016 1,780 3 View