Plasma protein controls of human serum are important to decide on the protein concentrations of the control plasma/serum. The control plasma/serum should contain plasma proteins within the reference ranges. Proteins such as Albumin, α1-glycoprotein, α1-antitrypsin, α2-macroglobulin, anti-streptolisyn O, Antithrombin III, β2-microglobulin, Ceruloplasmin, C3, C4, C-reactive protein, Haptoglobulin, IgA, IgG, IgM, Kappa, Lambda, Prealbumin, Rheumatoid Factor, Transferrin, Ferritin, IgE, Retinol binding protein have been assayed in human serum containing different concentrations of plasma protein suitable for the accuracy and precision control of the analytical methods in clinical laboratories. The disease group samples can have plasma protein contents that are not in the reference ranges and linked to the disease processes such as obesity, diabetes, NAFLD and neurodegenerative diseases. The anti-aging protein Sirtuin 1 is now shown to be associated with various diseases obesity, diabetes, NAFLD and neurodegenerative diseases. The protein concentration of Sirtuin 1 may decrease early in the disease process when compared with various other important disease protein markers. Sirtuin 1 (references 9-120, curriculum vitae attached) is involved with various biological and disease pathways and determines the survival of man and various species. Sirtuin 1 may need to be measured as a CONTROL PROTEIN with relevance to reversal of various chronic diseases and multiple organ disease syndrome.
RELEVANT REFERENCE:
1. PLASMA PROTEIN CONTROL N-I CE (LINEAR CHEMICALS, CROMATEST).
2. Curriculum Vitae Ian James Martins2021.
It is known now that sirtuins, when adjusting the pattern of cellular metabolism to nutrient availability, can regulate many metabolic functions significant from the standpoint of aging research – including DNA repair, genome stability, inflammatory response, apoptosis, cell cycle, and mitochondrial functions
Sirtuins are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. Homeostasis involves keeping the cell in balance. However, sirtuins can only function in the presence of NAD+, nicotinamide adenine dinucleotide, a coenzyme found in all living cells.
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INDEPENDENT SCIENTIST (Pride of Australia)
https://orcid.org/0000-0002-2390-1501
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Ian James Martins (Ph D, D.Sc and Dr.Med, Doctrin de Science, Honoris Causa)
International Press Release July 2020
Dr. Ian James Martins DSc (Honoris Causa) Doctrin De Science Award Honoris Causa
International Press Release September 2019
World's Famous Scientist Dr. Ian James Martins from Australia conferred with Honorary Degree of Doctor of Science for Outstanding Scientific Contribution in Nutrition. Dr. Ian Martins from Australia conferred with Honorary Degree of Doctor of Medicine for Outstanding Scientific Contribution in Diabetes]. (Honoris causa)
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