The anti-aging protein Sirtuin 1 is critical to the anti-aging process and the prevention of obesity, diabetes, NAFLD and neurodegenerative diseases. Low plasma Sirtuin 1 levels are linked to the progression of various chronic diseases and the accelerated aging processes. Sirtuin 1 repression is associated with mitophagy and programmed cell death. There are a number of pharmaceutical drugs used in various countries ( eg, Atorvastatin, Metformin, Simvastatin, Omeprazole, Amlodipine, Metoprolol, Acetaminophen hydrocodone, Albuterol etc). These drugs with long term consumption may need to be tested to assess the increase or decrease in plasma Sirtuin 1 levels. The binding of these pharmaceutical drugs to Sirtuin 1 may promote accelerated aging and programmed cell death in various global populations. The intricate interplay of multiple drug use with Sirtuin 1 may need to be determined with relevance to aging and chronic disease. Pharmacetical drug use and an elevation in Sirtuin 1 levels may reverse chronic disease progression.
RELEVANT REFERENCES:
1. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26
2. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. 2017; Vol. 3 No. 3:24.
3. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.
4. Dai H, Sinclair DA, Ellis JL, Steegborn C. Sirtuin activators and inhibitors: Promises, achievements, and challenges. Pharmacol Ther. 2018 Aug;188:140-154.
5. Insulin Therapy and Autoimmune Disease with Relevance to Nonalcoholic Fatty Liver Disease. Non Alcoholic Fatty Liver Disease. An Update. IntechOpen. 2018.
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