Yes, many Indian Spices are having beneficial effects in nafld and neuro degenerative diseases. Ginger, Curcuma longa, Cinnamon, Nutmeg, Pepper nigrum, red chili and many more contains many Flavonoid, Apigenin etc. which are having to control such disease conditions. Many research studies are published in this regards.

Research on the potential for drug interactions when herbs and spices are used for culinary purposes is meager. Spices are used in cooking and baking in smaller amount. Interactions may exist, but whether or not those interactions are clinically relevant is a matter of detailed study. Scientific studies of spices including anise, fennel, cayenne, parsley and several Indian spices also show no reports of clinically relevant interactions. Food and medication reactions is complicated and there are many other variables that need to be considered aside from the amount of spices, their variety, its potency, daily consumption, associated food, and metabolic pattern of medications might affect the interaction between the spice and drug. In fact, it is the dose that makes the poison. A very little amount of any spice with a recipe may not a likely cause for concern over drug interactions. However, the biological potency of particular spice should be taken in to account while consuming them with medication e.g. consumption of ginger and garlic should be avoided with anticoagulant drugs.

Drug - drug interaction is a possibility if the Specific Chemical and Specific Herb is consumed regular for a quite longer period like Anticoagulant Acitrom and Ginger, Comiphora mukul or Garlic etc. Purity of drugs, Bio-Availability, daily Dose, Vehicle, Diet and exercise also plays an important role.

The beneficial role of Spices in NAFLD is known since long in particular in Asian countries. Many scientific studies are conducted in this regard.

Please see this PUBLICATION:

Indian Spices and Unhealthy Diets interfere with Drug Therapy in Diabetes and Neurodegenerative Diseases.

2018; 3(4): 555616 DOI: 10.19080/NAPDD.2018.03.555616 002

Novel Approaches in Drug Designing & Development

KEY WORDS:

Indian Spices; Drug; Curcumin; Amyloid Beta; Metabolism; Cinnamon; Sirtuin ; Nutritional Therapy; NAFLD; Diabetes; Alzheimer’s Disease; Mitophagy; Bacterial Lipopolysaccharides

Spices have been used as flavoring, coloring and preservatives agents for thousands of years. Also spices have shown medicinal properties and influence on various body systems such as gastrointestinal, cardiovascular and reproductive and nervous systems. Researchers found antioxidants effects for some spices like Pimpinella anisum, curcuma longa, Crocus sativus, Piper nigrum, Ellitaria cardamom etc. which a causative factor for several ailments/health problems. Spices are the dried part of a plant that contain volatile oils or aromatic flavours such as, buds (cloves), bark (cinnamon), root (ginger), berries (black pepper), seeds (cumin, coriander). While consumption of spices is generally higher in Asian countries such as India, China, and Thailand, there has been an increasing trend in their intake in developed countries like Europe and USA, because of changing food habits and preference for ethnic and spicy food. In recent times measurement of dietary intake of spices is gaining much significance as various phytochemicals present in spices have been recognized to have health promoting benefits and preventive role in chronic diseases.

Pl go through a relevant paper available at following link:-

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326183/

Majority of spices, except chilli and turmeric, have intake levels below 1 g indicating the use of very low quantity of these spices in various dishes in most Asian countries. In other countries it is further lower. As such spice is not a food and basically used to improve the taste, flavour, colour and aroma of the food. Nowadays we are becoming more concerned about the quantity of intake of food. So spices are also getting increased attention. Spices are now also regarded for many petrochemicals having mostly beneficial roles. Apparently it should not interfere the drug therapy if the intake is so low. Traditional use of spices like chilli turmeric ginger etc has been tested with time. However there are enough scope of Research in this direction towards validation.

One typographical mistake.......petrochemicals to be replaced by phytochemicals.

Almost all spices are enhancing bio-availability of many nutrients and this is the reason the quantity is less than food itself, actually these acts as actives apart from enhancing Aroma, Taste, Flavor, Shelf-life and Anti microbial action.

Curcumin is a potent inducer of the heat shock response with complete interference of theheat shock gene Sirtuin 1 (Sirt 1) regulation of HSP 70. Curumin is a Sirt 1 inhibitor. Low dose CURCUMIN ingestion is indicated with other Indian spice consumption and their clearance from the body is poorly understood with higher dose curcumin involved with increased HSPs associated with amyloid beta aggregation induced toxicity .

REFERENCE: Martins IJ. Indian spices and Caffeine treatment for Obesity and Cardiovascular disease. Ann Clin Endocrinol Metabol. 2018; 2: 010-014.

Spices exhibit many potentially beneficial properties which appear to be sensitive in preventive and therapeutic action against a number of degenerative diseases. Spices are consumed in food with little quantity and there is no question of excessive accumulation in the brain and will not interfere with the astrocyte-neuron interaction and the suprachiasmatic nucleus with negative effect.

Dear Suresh K Malhotra,

Thank you for your mail. Please see below the 3 POINTS raised with regard to your answer. The major concern with INDIAN SPICES is with relevance to the interference with insulin therapy (HUMAN INSULIN BIOLOGICAL ACTIVITY) and with the anti-aging gene Sirtuin 1 deacetylase activity for the transcription factor p53 that regulates cell glucose and mitochondrial apoptosis.

1. Curcumin/Cinnamon effects on the insulin receptor and beta cell function modulates human insulin therapy with now critical consideration of Indian spice therapy REQUIRED with relevance to HUMAN INSULIN ADMINISTRATION and diabetes treatment. INSULIN THERAPY IN MAN needs to be carefully assessed with relevance combined therapy (Insulin Therapy/Indian spice therapy) and increased cellular glucose levels related to HYPERGLCYEMIA INDUCED MITOCHONDRIAL APOPTOSIS.

2. Indian spices that induce cell apoptosis prevent cancer include curcumin (turmeric) and piperine (black pepper) and active spice component pharmacokinetic data is still not available. The SPICE-DRUG interaction in the brain is of considerable concern since in the CURRENT GLOBAL NEURODEGENERATIVE DISEASE EPIDEMIC altered SPICE-DRUG interaction may be responsible for the mitochondrial apoptosis and neuron apoptosis.

3. Curcumin interferes with the transcription factor p53 in many published studies. The anti-aging gene Sirtuin 1 that determines mitochondrial biogenesis deacetylates transcription factor p53 and determines cell glucose levels and hyperglycemic mitochondrial apoptosis. Curcumin doses with the aging process needs to be carefully regulated in the current global NAFLD epidemic to prevent excessive curcumin induced neuron apoptosis (interference with cell Sirtuin 1/ p53 / glucose levels).

ONLINE ARTICLES:

1. Indian Spices and Insulin Therapy in Diabetes and Neurodegenerative Diseases.J Diab Clin Stud. 2018; Volume 1(1).

2. Indian spices and Caffeine treatment for Obesity and Cardiovascular Ann Clin Endocrinol Metabol. 2018; 2: 010-014

3. Indian Spices and Unhealthy Diets interfere with Drug Therapy in Diabetes and Neurodegenerative Diseases. NAPDD 002 2018; 3(4):555616.

4. Insulin Therapy Inactivation is connected to NAFLD and Diabetes Severity Index. J Diab Clin Stud. 2017; 1: 001-003.

5. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.

6. Early diagnosis of neuron mitochondrial dysfunction may reverse global metabolic and neurodegenerative disease. Global Journal of Medical Research.. 2016;2: 1-8.

7. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26.

8. Diet and Nutrition reverse Type 3 Diabetes and Accelerated Aging linked to Global chronic diseases. J Diab Res Ther. 2016; 2(2)

9. SUBMITTED ARTICLE: Manuscript ID: 8204280

Title: Indian spices and Biotherapeutics in Health and Chronic Disease. HEALTH

10. Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global communities. Journal of Molecular and Genetic Medicine. 2015; 9(1).

11. Nutritional and Genotoxic Stress Contributes to Diabetes and Neurodegenerative Diseases such as Parkinson's and Alzheimer's Diseases. - Frontiers in Clinical Drug Research -CNS and Neurological Disorders. Volume 3 Editor: Atta-ur-Rahman Pp. 158-192 (35)

OTHER REFERENCES:

Yours sincerely,

Ian Martins (Ph D)

Fellow of International Agency for Standards and Ratings (IASR)

Centre of Excellence for Alzheimer's Disease Research and Care Sarich Neuroscience Research Institute

Edith Cowan University

8 Verdun Street, Nedlands 6009.

Western Australia, Australia