Interests in Biomarker Research has escalated with relevance to mitochondrial survival and global organ disease in diabetes and Alzheimer’s disease. Biomarker Research is expected to cost approx 118 billion dollars in the next 10 years. Bacterial lipopolysaccharides (LPS) should be measured in the blood plasma of developing world individuals with relevance to mitochondrial apoptosis and global chronic disease. The anti-aging protein such as Sirtuin 1 may also now be relevant to mitochondrial apoptosis versus mitochondrial biogenesis and may supersede the various biomarkers for mitochondrial survival relevant to diabetes, Alzheimer’s disease and neurodegenerative disease research.
RELEVANT REFERENCES:
1. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3.
2. Early diagnosis of neuron mitochondrial dysfunction may reverse global metabolic and neurodegenerative disease. Global Journal of Medical Research.. 2016;2: 1-8.
3. Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease. Proteomes, 2016. 4(2) 1-19.
4. The Future of Biomarkers Tests and Genomic Medicine in Global Organ Disease. Microbiology and Infectious Diseases. 2017; 1(1): 1-6.
5. Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global communities. Journal of Molecular and Genetic Medicine: 03/2015; 9(1).
6. Diabetes and Organ Dysfunction in the Developing and Developed. Global Journal of Medical Research: F Diseases Volume 15 Issue 1 Version 1.0 Year 2015.
7. The Future of Genomic Medicine Involves the Maintenance of Sirtuin 1 in Global Populations. Int J Mol Biol . 2017. 2(1): 00013.
8. Dietary Interventions Reverse Insulin and Synaptic Plasticity Defects Linking to Diabetes and Neurodegenerative Diseases. SL Nutrition and Metabolism. 2017; 1:111:1-5.
9. Bacterial Lipopolysaccharides Change Membrane Fluidity with Relevance to Phospholipid and Amyloid Beta Dynamics in Alzheimer’s Disease. J Microb Biochem Technol. 2016; 8: 322-324. 10. LPS Regulates Apolipoprotein E and Aβ Interactions with Effects on Acute Phase Proteins and Amyloidosis. Advances in Aging Research 03/2015; 4(2):69-77.
11. Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. Int J Mol Sci. 2015; 16(12): 29554–29573.
12. Bacterial LPS Overrides Adenosine Treatment of Epileptic Seizures. EC Microbiology 7.3 (2017): 83-86.
13. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.
14. The global biomarkers market size is expected to reach over USD 118 billion by 2026 https://www.prnewswire.com/news-releases/the-global-biomarkers-market-size-is-expected-to-reach-over-usd-118-billion-by-2026-300836830.htm
I think that indeed it is relevant to measure the LPS levels in the blood, however, I don't think that this will directly measure the mitochondrial apoptosis... perhaps w specific mitochondrial protein would be more specific... but it is a interesting biomarker.
best regards
Dear Dr Monnerat,
Thank you for your mail.
Yours sincerely,
Ian Martins (Ph D)
Fellow of International Agency for Standards and Ratings (IASR) https://sites.google.com/site/internationalindexing/advisory-board
Centre of Excellence for Alzheimer's Disease Research and Care Sarich Neuroscience Research Institute
Edith Cowan University 8 Verdun Street, Nedlands 6009. Western Australia, Australia
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