ABSTRACT
General anesthesia, Sedation, Regional anesthesia and local anesthesia (doses of one or more drugs) and the types of drugs used include general anesthetics, hypnotics, sedatives, neuromuscular-blocking drugs, narcotic, and analgesics.
1. These various compounds may EFFECT the heat shock gene with complete inactivation of the gene during ANAESTHESIA.
2. Specific drugs/analgesics (CHEMICALS) may ACTIVATE OR inactivate the gene that is critical to neuron function and lifespan.
3. After anaesthesia specific drugs may not allow heat shock gene activation (irreversible) and several hours need to lapse for heat shock gene activation after anaesthesia.
Dr Ian James Martins is on the EDITORIAL BOARD of CPQ Anaesthesia and Pain Management.
RELEVANT REFERENCES
A. Heat Shock Gene Inactivation and Protein Aggregation with Links to Chronic Diseases. Diseases. 2018, 6;39:1-5.
B. Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals. International Journal of Aging Research. 2018,1(6): 1-4.
C. Heat Shock Gene Dysregulation and Inactivation of Drug Therapy. EC Pharmacology and Toxicology. ECO.01 (2017): 13-15.
D. Early diagnosis of neuron mitochondrial dysfunction may reverse global metabolic and neurodegenerative disease. Global Journal of Medical Research. 2016;2: 1-8.