Nutritional science has provided functional foods with the required amounts of natural antioxidants, vitamins, fats, proteins, polyphenols, carbohydrates, and other components required to maintain the cell function and prevent programmed cell death. Food scientists have developed essential strategies such as high fibre diets to treat chronic neurodegenerative disease that are now associated with obesity and diabetes and linked to the developing and developed world. The use of dietary supplements and functional foods in human nutrition may therefore be promising for preventing or counteracting metabolic disorders and related diseases. Short chain fatty acids (SCFA) now have reported to be a more biologically active component in the treatment of diabetes cognition, brain disorders and Alzheimer’s disease (AD). SCFAs are a subset of fatty acids that are produced by the gut microbiota during the fermentation of dietary fibres. It is understood that fibre is converted into SCFAs by bacteria, these are 2-carbon to 5-carbon weak acids, mainly acetate (C2), propionate (C3), butyrate (C4) and valerate (C5). SCFA such as butyric acid may be a critical strategy as an HDAC inhibitor to determine the effectiveness of various functional foods in the treatment of diabetes and Alzheimer’s disease.
RELEVANT REFERENCES:
1. Fernando WMADB, Martins IJ, Morici M, Bharadwaj P, Rainey-Smith SR, Lim WLF, Martins RN. Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer's Disease Transgenic Mouse Model at an Early Disease Stage. J Alzheimers Dis. 2020;74(1):91-99.
2. Functional Foods and Active molecules with relevance to Health and Chronic disease: Editorial. Functional Foods in Health and Disease 2017; 7(10): 833-836.
3. Biotherapy and the Immune System in Ageing Science. Acta Scientific Nutritional Health 2.4 (2018): 29-31.
4. Indian Spices and Biotherapeutics in Health and Chronic Disease. Health, 2018; 10, 374-380. 5. Caffeine with Links to NAFLD and Accelerated Brain Aging. Chapter: Non-Alcoholic Fatty Liver Disease - Molecular Bases, Prevention and Treatment. InTech - Open Science Open Minds | InTechOpen. 2017.
6. High Fibre Diets and Alzheimer’s Disease. Food and Nutrition Sciences (Diet and Disease), Vol. 5 No. 4, 410-424.
The friendly bacteria produce short-chain fatty acids in your gut.
They are the primary source of nutrition for the cells in your colon.
Short-chain fatty acids may also play an essential role in health and disease.
They may reduce the risk of inflammatory diseases, type 2 diabetes, obesity, heart disease, and other conditions
A review of the evidence reported that butyrate could have positive effects in both animals and humans with type 2 diabetes studies have identified a crucial role of the gut microbiome in modifying Alzheimer's disease (AD) progression
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