The interest in the peptide apelin that has been identified as an anti-aging factor has escalated and its inactivation leads to inactivation of the anti-aging gene Sirtuin 1. Accelerated aging and programmed cell death that is linked to endocrinology, diabetes and neurodegenerative disease is now associated with reduced apelin levels and the anti-aging Sirtuin 1 protein levels.
RELEVANT REFERENCE: Appetite dysregulation and the apelinergic system are connected to global chronic disease epidemic. Series of Endocrinology, Diabetes and Metabolism. 2020;1:67-69.