24 November 2022 1 4K Report

The literature indicates that yoghurt contains live bacteria that have major effects on gut dysbiosis, metabolism, insulin resistance and neurodegeneration. Gram negative bacteria release bacterial lipopolysaccharides (LPS) that have critical effects on insulin resistance and amyloid beta aggregation with relevance to diabetes and Alzheimer’s disease. The use of yoghurt, cheese and milk should be used to reduce gram negative bacteria and reduce plasma LPS levels that are markedly elevated in the developing and third world individuals.

RELEVANT REFERENCES:

1. Le Roy CI, Kurilshikov A, Leeming ER, et al. Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome [published correction appears in BMC Microbiol. 2022 Feb 28;22(1):66]. BMC Microbiol. 2022;22(1):39.

2. Lisko DJ, Johnston GP, Johnston CG. Effects of Dietary Yogurt on the Healthy Human Gastrointestinal (GI) Microbiome. Microorganisms. 2017;5(1):6.

3. Aslam H, Marx W, Rocks T, et al. The effects of dairy and dairy derivatives on the gut microbiota: a systematic literature review. Gut Microbes. 2020;12(1):1799533.

4. Le Roy, C.I., Kurilshikov, A., Leeming, E.R. et al. Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome. BMC Microbiol 22, 39 (2022).

5. V Yu Kontareva et al. Yogurt enriched to correct intestinal microflora in dysbiosis. 2020 IOP Conf. Ser.: Earth Environ. Sci. 548 082051.

6. Suzuki Y, Ikeda K, Sakuma K, Kawai S, Sawaki K, Asahara T, Takahashi T, Tsuji H, Nomoto K, Nagpal R, Wang C, Nagata S, Yamashiro Y. Association between Yogurt Consumption and Intestinal Microbiota in Healthy Young Adults Differs by Host Gender. Front Microbiol. 2017 May 11;8:847.

7. LPS Regulates Apolipoprotein E and Aβ Interactions with Effects on Acute Phase Proteins and Amyloidosis. Advances in Aging Research 03/2015; 4(2):69-77.

8. Unhealthy Diets Determine Benign or Toxic Amyloid Beta States and Promote Brain Amyloid Beta Aggregation. Austin J Clin Neurol 2015;2(7): 1060-66.

9. Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. Int J Mol Sci. 2015;16(12): 29554–29573.

10. The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease. Proteomes, 2016. 4(2) 1-19.

11. Food quality induces a miscible disease with relevance to Alzheimer’s disease and Neurological diseases, J Food Research, vol. 5, pp.45-52, 2016.

12. Bacterial Lipopolysaccharides Change Membrane Fluidity with Relevance to Phospholipid and Amyloid Beta Dynamics in Alzheimer’s Disease. J Microb Biochem Technol. 2016; 8: 322-324.

13. The Future of Genomic Medicine Involves the Maintenance of Sirtuin 1 in Global Populations. Int J Mol Biol . 2017. 2(1): 00013.

14. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3.

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