The early diagnosis of Alzheimer's disease (AD) has become important to the reversal and treatment of neurodegeneration which may be relevant to premature brain aging associated with chronic disease progression. The diagnosis of AD by various plasma biomarkers with clinical proteomics may now require the involvement of lipidomics and genomics to provide interpretation of proteomic results from various laboratories around the world. The high fat, high fibre and high carbohydrate diets may influence and determine the variability of the various plasma biomarkers with relevance to the early diagnosis of AD. The measurements of AD blood biomarkers may need to be assessed in both the fasting and feeding states to allow early, accurate and reproducible diagnosis of AD.
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Ian J Martins It is recommended to choose whether to fast or not according to the type of marker and the purpose of the test. For example, for markers that may be affected by insulin or blood sugar fluctuations, it may be more reliable to measure in a fasting state. For more stable protein markers, there may not be a strict fasting requirement. The fasting state may be helpful for certain specific biomarkers, but whether fasting is necessary should be based on the specific test requirements and marker characteristics.
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