Can defective PHOSPHOLIPID DYNAMICS be the primary defect in the peripheral sink amyloid beta clearance pathway in DISEASES and Alzheimer’s disease?

07 June 2019 0 4K Report

PLEASE SEE ATTACHED FIGURE ENTITLED: DYNAMIIC PHOSPHOLIPID METABOLISM IS CONTROLLED BY SIRTUIN 1.

RELEVANT REFERENCES:

1. I.J.Martins and T.G. Redgrave. 1992. The effects of Insulin-deficiency on the metabolism of High Density Lipoprotein Phospholipids in Rats. Biochem J. 281: 851-857.

2. I.J.Martins, L. Hopkins, C. Joll and T.G. Redgrave. 1991. Interactions between triacylglycerol-rich Model lipoproteins and High Density lipoproteins in rat, rabbit and man. Biochim. Biophys.Acta. 1081: 328-338.

3. N.P. Lenzo, I.J. Martins, B. C. Mortimer and T.G. Redgrave. 1988. Effects of phospholipid composition on the metabolism of triacylglycerol, cholesteryl ester and phosphatidylcholine from lipid emulsions injected intravenously in rats. Biochim. Biophys. Acta. 960: 111-18.

4. I.J. Martins, N.P. Lenzo and T.G. Redgrave. 1989. Phosphatidylcholine metabolism after transfer from lipid emulsions injected intravenously into rats. Implications for High Density lipoprotein metabolism. Biochim. Biophys. Acta. 1005: 217-224.

5. Martins IJ. Appetite Regulation and the Peripheral Sink Amyloid beta Clearance Pathway in Diabetes and Alzheimer’s Disease. Top 10 Commentaries in Alzheimer’s Disease (e-book). 2019;2:1-11. www.avidscience.com

6. Martins IJ. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.

7. Martins IJ. Calorie Sensitive Anti-Aging Gene Regulates Hepatic Amyloid Beta Clearance in Diabetes and Neurodegenerative Diseases”. EC Nutrition ECO.01 (2017): 30-32.

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