The purposes of drug therapy is to help with the treatment or even cure of a disease process. When prescribing drugs for the individual patient, guidelines, formularies and other prescribing aids are required and the prescriber needs to establish what the patient’s experience and expectations of drug therapy are and the patient needs to know the likely consequences—both good and bad—of taking any drug that is prescribed. Patient compliance is a key variable in the prescribing process and drug therapy. The role of drug therapy and treatment of patients may require the critical activation of key anti-aging genes that prevent programmed cell death. Drug therapy over days, weeks and months that inactivates anti-aging genes such as Sirtuin 1 may need to stopped to prevent serious complications such as programmed cell death and multiple organ disease syndrome. Drug therapy in various obese, diabetic, NAFLD and neurodegenerative diseases may require the consumption of Sirtuin 1 activators that may protect against the side effects of drug therapy.

RELEVANT REFERENCES:

1. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26.

2. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. 2017;Vol. 3 No. 3:24.

3. Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes. J Diabetes Metab Disord. 2017; 4: 019.

4. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions. EC Pharmacology and Toxicology 6.4 (2018): 209-215.

5. Firth, John D. and others (eds), 'Principles of clinical pharmacology and drug therapy' in John Firth, Christopher Conlon, and Timothy Cox (eds), Oxford Textbook of Medicine, 6 edn (Oxford, 2020; online edn, Oxford Academic, 1 Jan. 2020).

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