ABSTRACT

Genomic medicine treatment of diabetics is critical in the current global diabetes epidemic to prevent the expected diabetes pandemic predicted to occur by the year 2035. The major concern with Type 3 diabetes in the global population is related to a defective SCN with relevance to uncontrolled peripheral glucose levels and endocrine autoimmune disease. Appetite regulation and genomic medicine are critical to Sirt 1’s regulation of the MHC genes with relevance to maintenance of immune recognition and endocrine hormone treatment of mitophagy. In the developing world the major concern for a diabetes pandemic is mitophagy and will require diets with Sirt 1 activators to prevent Type 3 diabetes, endocrine autoimmunity and mitochondrial disease.

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