Heroin abusers are associated with accelerated aging and neurodegenerative disease. The cellular effects of heroin is possibly linked to mitochondrial apoptosis. The risk of uncontrolled heroin consumption may lead to multiple organ disease syndrome and the risk of death. Heroin addicts have altered immune system and core body temperature defects that may lead to chronic disease. Heroin addicts may have an increase risk for stroke and intraparenchymal hemorrhage. The inactivation of the anti-aging gene Sirtuin 1 is associated with accelerated aging, stroke and neurodegenerative disease. Sirutin 1 is important to core body temperature and immune reactions that is linked to neurodegenerative disease. Heroin may inhibit Sirtuin 1 and accelerate mitochondrial apoptois with relevance to multiple organ disease syndrome. Sirtuin 1 regulates telomerase that is critical to biological aging. Exercise and mindfulness decompression therapy that can improve the social anxiety level of heroin withdrawal patients and may involve the activation of Sirtuin 1. Nutritional diets that activate Sirtuin 1 may be critical to prevent the accelerated aging and neurodegenerative disease in heroin abusers and addicts.
THE DOSE OF HEROIN IN ADDICTS AND ABUSERS SHOULD BE CAREFULLY CONTROLLED TO PREVENT SIRTUIN 1 INHIBITION AND THE INDUCTION OF PROGRAMMED CELL DEATH.
RELEVANT REFERENCES:
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2. Cheng, G., Zeng, H., Leung, MK. et al. Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction. Transl Psychiatry 3, e260 (2013).
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Xia B, Li Y, Li R, Yin D, Chen X, Li J, Liang W. Effect of Sirtuin-1 on Synaptic Plasticity in Nucleus Accumbens in a Rat Model of Heroin Addiction. Med Sci Monit. 2018 Jun 5;24:3789-3803. doi: 10.12659/MSM.910550
Morphines, in general, are known to enhance the expression of SIRT1 (see 10.1016/j.neulet.2020.135599). I would be surprised to see that diacetylmorphine inhibits SIRT1. Perhaps overexpression of SIRT1 leads to adverse consequences.
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