Therapeutics such as probiotics exert a beneficial effect on host gut microbiota after consumption and may be capable to prevent several diseases such as Alzheimer’s disease. Fermented dairy foods, cheese whey and buttermilk whey offer suitable matrices for the growth and viability of probiotic microorganisms and are potential sources for the development of probiotic dairy-based beverages. The literature shows that the heterogeneous food matrices of non-dairy food carriers are the major constraints for the survival of the probiotics and the use of antioxidants in yogurt manufacture. Dairy consumption such as sour/fermented milk, yogurt, cheese, butter/cream, ice cream, and infant formula need to be assessed for the content of microbial diversity. The role of fermentation, freezing/thawing, room temperature modification and probiotic shelf life may have a critical effect on the generation of LPS from gram negative bacteria that may lead to dysbiosis. The association between high fat/high cholesterol diets have been shown to be linked to the increased incidence for Alzheimer’s disease (AD). The literature shows strong evidence with relevance to changes in cholesterol metabolism and transport that is associated with AD pathogenic processes. The safety of probiotic therapy for AD patients requires investigation with relevance to the induction of dyslipidemia and the release of bacterial lipopolysaccharides and amyloid beta from gram-negative bacteria needs to be controlled in these probiotic formulations.
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Dear Emad Hussein,
Thank you for this very important answer.
Ian James Martins (PhD, D.Sc and Dr.Med, Doctrin de Science, Honoris Causa) https://orcid.org/0000-0002-2390-1501
ABCD Wall Life Journey and career: https://youtu.be/cYy4OmTkKvY?t=21
INDEPENDENT SCIENTIST (Pride of Australia) https://sites.google.com/site/internationalindexing/advisory-board International Press Release July 2020 Dr. Ian James Martins DSc (Honoris Causa) Doctrin De Science Award Honoris Causa International Press Release September 2019 World's Famous Scientist Dr. Ian James Martins from Australia conferred with Honorary Degree of Doctor of Science for Outstanding Scientific Contribution in Nutrition. Dr. Ian Martins from Australia conferred with Honorary Degree of Doctor of Medicine for Outstanding Scientific Contribution in Diabetes]. (Honoris causa) Fellow of International Agency for Standards and Ratings (IASR)
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