The major risk of overconsumption of a high fibre diet will lead to excessive intake of phytosterols that lead to neurodegeneration. Diets that are high in fibre in the developing world may also contain toxic xenobiotics that may lead to insulin resistance, NAFLD cardiovascular disease and brain damage.
Overconsuption of any very useful food may turn into harmful effect following dose-related response
It is very interesting concept. I am a Paediatric Gastroenterologist. I have seen many doctors advice to increase fiber consumption to manage functional gastrointestinal diseases like constipation and IBS despite no data support the intervention. I would like to thank you for sharing this information so that I can use it in my teaching and consultations in future.
What we see in the US is very poor and very low fiber diet. NAFLD and NASH, obesity and even cardiovascular disease tend to associate rather with obesity, high fat and low fiber diet. I would not change my clinical recommendation of healthy fiber intake in the US unless I would find compelling studies done in industrialized countries showing a detrimental effect of fiber intake. At this point as far as I am aware a plant based diet containing at least 20-25 grams of fiber per day is the healthiest for most people in the industrialized world.
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