The literature indicates that low-dosage aspirin administration as an anti-aging agent has evolved from the multitude of properties associated with aspirin to prevent the cellular and functional declines from inflammatory and oxidative sources linked to aging. The anti-aging gene Sirtuin 1 is associated with the reversal of cell senescence and accelerated aging. Aspirin has been shown to be a Sirtuin 1 activator and the low dosage aspirin administration may be important to increase life span in global populations.
RELEVANT REFERENCES:
A. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26.
B. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. 2017;Vol. 3 No. 3:24.
C. Phillips T, Leeuwenburgh C. Lifelong aspirin supplementation as a means to extending life span. Rejuvenation Res. 2004 Winter;7(4):243-51. doi: 10.1089/rej.2004.7.243.
D. Ariela R Orkaby, Laiji Yang, Alyssa B Dufour, Thomas G Travison, Howard D Sesso, Jane A Driver, Luc Djousse, J Michael Gaziano. Association Between Long-Term Aspirin Use and Frailty in Men: The Physicians’ Health Study, The Journals of Gerontology: Series A, Volume 76, Issue 6, June 2021, Pages 1077–1083.
E. Federico Pietrocola, Francesca Castoldi, Maria Markaki, Sylvie Lachkar, Guo Chen, David P. Enot, Sylvere Durand, Noelie Bossut, Mingming Tong, Shoaib A. Malik, Friedemann Loos, Nicolas Dupont, Guillermo Mariño, Nejma Abdelkader, Frank Madeo, Maria Chiara Maiuri, Romano Kroemer, Patrice Codogno, Junichi Sadoshima, Nektarios Tavernarakis, Guido Kroemer. Aspirin Recapitulates Features of Caloric Restriction, Cell Reports, Volume 22, Issue 9, 2018, Pages 2395-2407.
F. Kamble P, Kulkarni S (2018) Induction of Sirt1 and PGC1α Signalling Pathway in Cardiac Mitochondrial Biogenesis by Aspirin. Eur Exp Biol. Vol. 8 No. 1:6.
G. Kamble P, Selvarajan K, Aluganti Narasimhulu C, Nandave M, Parthasarathy S. Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1α genes. Eur J Pharmacol. 2013 Jan 15;699(1-3):55-61.
H. Jung YR, Kim EJ, Choi HJ, Park JJ, Kim HS, Lee YJ, Park MJ, Lee M. Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells. Mol Pharmacol. 2015 Oct;88(4):708-19.
I. Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes. J Diabetes Metab Disord. 2017; 4: 019.
J. Zaini MA, Müller C, de Jong TV, Ackermann T, Hartleben G, Kortman G, Gührs KH, Fusetti F, Krämer OH, Guryev V, Calkhoven CF. A p300 and SIRT1 Regulated Acetylation Switch of C/EBPα Controls Mitochondrial Function. Cell Rep. 2018 Jan 9;22(2):497-511.
K. Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, Hay RT, Gu W, Pestell RG. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem. 2005 Mar 18;280(11):10264-76.
- Badges
- Science topic