Butyric acid regulates gene expression by inhibiting histone deacetylases (HDACs). Butyrate induces growth arrest in a variety of normal cell types and senescence-like cancer cells by inhibiting DNA synthesis and cell growth and inducing stem cell differentiation and apoptosis by DNA fragmentation. Butyric acid regulates gene expression by inhibiting histone deacetylases (HDACs). Butyric acid has been assessed in NAFLD and Alzheimer’s disease as a therapeutic agent. The anti-aging gene Sirtuin 1 is a histone deacetylase and HDAC inhibition may completely interfere with its role in anti-aging and DNA repair and regulation of programmed cell death pathways.
RELEVANT REFERENCES
1. Ho L, Ono K, Tsuji M, Mazzola P, Singh R, Pasinetti GM. Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms. Expert Rev Neurother. 2018 Jan;18(1):83-90.
2. Kosta Steliou, Michael S. Boosalis, Susan P. Perrine, José Sangerman, and Douglas V. Faller. Butyrate Histone Deacetylase Inhibitors. Biores Open Access. 2012 Aug; 1(4): 192–198. 3. Bourassa MW, Alim I, Bultman SJ, Ratan RR. Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health? Neurosci Lett. 2016 Jun 20;625:56-63.
4. Eva Juárez-Hernández, Norberto C. Chávez-Tapia, Misael Uribe, and Varenka J. Barbero-Becerra. Role of bioactive fatty acids in nonalcoholic fatty liver disease. Nutr J. 2016; 15: 72.
5. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26
6. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. 2017; Vol. 3 No. 3:24.
7. Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals. International Journal of Aging Research. 2018,1(6): 1-4.
"Re-evaluated"? I think a lot of momentum on this never stopped, although some new life presently thrives under term BHB (Beta hydroxybutryate). I.e. low carb, ketogenic, ketones and their metabolic impact Not the same as butyric acid, but I suspect connecting pathways are direct enough to account for a fair share of overlap in experimental impact.
Just noticing your research on temperature. Just a suggestion of mine, to consider butyric acid along with BHB as 4-carbon metabolism link to body temperature via UCP up-regulation of beige adipose.
Ex:
DOI: 10.1016/j.cmet.2019.05.005
https://pubmed.ncbi.nlm.nih.gov/31155495-a-prdm16-driven-metabolic-signal-from-adipocytes-regulates-precursor-cell-fate/?from_single_result=BHB+UCP1
Similar: BHB mito upreg in skeletal :
Article β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in...
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