RELEVANT REFERENCES: Polypharmacy (Antipsy: antipsychotic, antidepress: antidepressant, cholesterol lowering drugs, aspirin, etc)
1. Scott T. Chiesa and Marietta Charakida. High-Density Lipoprotein Function and Dysfunction in Health and Disease. Cardiovasc Drugs Ther. 2019; 33(2): 207–219.
2. uth Birner-Gruenberger, Matthias Schittmayer, Michael Holzer, Gunther Marsche. Understanding high-density lipoprotein function in disease: Recent advances in proteomics unravel the complexity of its composition and biology. Progress in Lipid Research, Volume 56, 2014, Pages 36-46.
3. Correll CU, Frederickson AM, Kane JM, Manu P. Does antipsychotic polypharmacy increase the risk for metabolic syndrome? Schizophr Res. 2007 Jan;89(1-3):91-100.
4. Akshar Y. Patel, Pratik Shah, and Joseph H. Flaherty. Number of medications is associated with outcomes in the elderly patient with metabolic syndrome. J Geriatr Cardiol. 2012 Sep; 9(3): 213–219.
5. Ono, S, Sugai, T, Suzuki, Y. et al. High-density lipoprotein-cholesterol and antipsychotic medication in overweight inpatients with schizophrenia: post-hoc analysis of a Japanese nationwide survey. BMC Psychiatry 18, 180 (2018).
6. Saari K, Koponen H, Laitinen J, Jokelainen J, Lauren L, Isohanni M, Lindeman S. Hyperlipidemia in persons using antipsychotic medication: a general population-based birth cohort study. J Clin Psychiatry. 2004 Apr;65(4):547-50.
Hi,
With Antipsychotics:
"Marked differences exist between antipsychotics in terms of metabolic side-effects, with olanzapine and clozapine exhibiting the worst profiles and aripiprazole, brexpiprazole, cariprazine, lurasidone, and ziprasidone the most benign profiles."
Ref:Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD. Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. Lancet Psychiatry. 2020 Jan;7(1):64-77. doi: 10.1016/S2215-0366(19)30416-X
Antipsychotics and HDL:
Article High-density lipoprotein-cholesterol and antipsychotic medic...
or
Ono, S., Sugai, T., Suzuki, Y., Yamazaki, M., Shimoda, K., Mori, T., Ozeki, Y., Matsuda, H., Sugawara, N., Yasui-Furukori, N., Okamoto, K., Sagae, T., & Someya, T. (2018). High-density lipoprotein-cholesterol and antipsychotic medication in overweight inpatients with schizophrenia: post-hoc analysis of a Japanese nationwide survey. BMC psychiatry, 18(1), 180. https://doi.org/10.1186/s12888-018-1764-1
With Antidepressants;
"Overall, the results of the mini-review seem to support the association among depressive symptoms, antidepressants therapy and MetS......the relationship between antidepressants and MetS still needs to be clarified. Considering the widespread prescription of antidepressants, both on behalf of psychiatrists and primary care physicians, further research on this topic is recommended."
Ref : Gramaglia, C., Gambaro, E., Bartolomei, G., Camera, P., Chiarelli-Serra, M., Lorenzini, L., & Zeppegno, P. (2018). Increased Risk of Metabolic Syndrome in Antidepressants Users: A Mini Review. Frontiers in psychiatry, 9, 621. https://doi.org/10.3389/fpsyt.2018.00621.
Antidepressants on Lipoproteins:
Hummel J, Westphal S, Weber-Hamann B, Gilles M, Lederbogen F, Angermeier T, Luley C, Deuschle M, Kopf D. Serum lipoproteins improve after successful pharmacologic antidepressant treatment: a randomized open-label prospective trial. J Clin Psychiatry. 2011 Jul;72(7):885-91. doi: 10.4088/JCP.09m05853blu
Diabetics with metabolic syndrome are already at a higher risk.
On Combination Ads and Aps:
Effects of antidepressant and antipsychotic use on weight gain: A systematic review
Lucia Alonso‐Pedrero
Maira Bes‐Rastrollo
Amelia Marti
First published: 16 September 2019
https://doi.org/10.1111/obr.12934
Aspirin on HDL:
Ref to table 1 of the referenced article showing no effect on HDL:
Lou, G., Chen, J. & Xia, Y. Effects of low-dose aspirin in subjects with dyslipidemia. Lipids Health Dis 15, 106 (2016). https://doi.org/10.1186/s12944-016-0274-8
Dear Dr Anand,
Thank you for your mail.
Yours sincerely, I
an James Martins (Ph D, D.Sc and Dr.Med, Doctrin de Science, Honoris Causa) International Press Release July 2020 Dr. Ian James Martins DSc (Honoris Causa) Doctrin De Science Award Honoris Causa International Press Release September 2019 World's Famous Scientist Dr. Ian James Martins from Australia conferred with Honorary Degree of Doctor of Science for Outstanding Scientific Contribution in Nutrition. Dr. Ian Martins from Australia conferred with Honorary Degree of Doctor of Medicine for Outstanding Scientific Contribution in Diabetes]. (Honoris causa) Fellow of International Agency for Standards and Ratings (IASR)
Division for Certification and Accreditation https://sites.google.com/site/internationalindexing/advisory-board
All antipsych increase cholesterol. Lowering the HDL/LDL quota. Different antipsych increase by different levels
Some antidepressant do the same. Mirtazapin, mianserin and amitryptiline being the most likely.
Aspirin does not change the cholesterol profile
Dear Knape,
Thank you for your mail.
Yours sincerely,
Ian James Martins (Ph D, D.Sc and Dr.Med, Doctrin de Science, Honoris Causa)
International Press Release July 2020
Dr. Ian James Martins DSc (Honoris Causa) Doctrin De Science Award Honoris Causa
International Press Release September 2019
World's Famous Scientist Dr. Ian James Martins from Australia conferred with Honorary Degree of Doctor of Science for Outstanding Scientific Contribution in Nutrition. Dr. Ian Martins from Australia conferred with Honorary Degree of Doctor of Medicine for Outstanding Scientific Contribution in Diabetes]. (Honoris causa)
Fellow of International Agency for Standards and Ratings (IASR)
Division for Certification and Accreditation
https://sites.google.com/site/internationalindexing/advisory-board
- Badges
- Science topic
- Similar topics
- Psychology