CERTIFICATE FOR EXCEPTIONAL EFFORT
Please see Presentation below entitled
" Drug-Drug Interactions with Relevance to Drug Induced Mitochondrial Toxicity and Accelerated Global Chronic Diseases"
at the 8th World Gene Convention-2017.
Perturbation of mitochondria by drugs can lead to an increased longevity. This was demonstrated to be true for the filamentous ascomycete Podospora anserina which is a model for ageing studies. Please check this paper:
https://www.ncbi.nlm.nih.gov/pubmed/24177587
Cheers, Christian
The example of Dr. Christian Q. Scheckhuber is for simple organisms. However, wit more complex and longer living organisms, there is a risk that that if you block reproduction of mitochondria, the organism will die young. Aging is a very complex process and different organs age at different pace. On my page I just posted few papers, which discuss this issue.
I agree with Dr. Panov. Furthermore, aging in Podospora anserina is associated with severe mtDNA rearrangements. This process is not found in higher systems (although non-dividing cells in aged individuals contain also mtDNA reorganisations, but to a far lesser degree compared to Podospora). EtBr mainly inhibits the Podospora-specific gross rearranvement of mtDNA (e. g., formation and accumulation of sub circles). So it rather interferes with a 'private' than a 'public' mechanism of aging.
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