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Questions related to Drugs
Dear sir/ mam, In-vitro diffusion studies of developed formulation was performed, by using the Franz diffusion cell. how can i calculate the amount of drug permeated through membrane at...
04 January 2022 8,607 1 View
As a Masters Project I'll be working on analysis of EEG data. So I have EEG data which when loaded in Matlab shows 32*384*80. Can anyone explain what is channels, epochs in EEG data?
03 January 2022 3,009 3 View
I m investigating sirtuin1 and sirtuin 2 gene expression in the 3T3-L1 preadipocyte cell line. What would you recommend for protein analysis instead of western? thank you, Ezgi
02 January 2022 568 1 View
Some metabolites of plant are present exclusively in some parts of the plant. Kindly provide some references too if possible.
31 December 2021 8,072 4 View
In particular, the tissue seems to have lost its ability to withstand compression. The soft tissue of the body seems to be compressed by gravity and its own weight. Can someone link articles that...
27 December 2021 863 0 View
Induction of hyper and hypothyroidism in rats by drugs (LT4 and carbimazole), is the protocol scientifically valid to study the effect of bioactive compounds against thyroid dysfunction?...
23 December 2021 5,697 3 View
We are trying to formulate Albendazole suspension (for animals) using different suspending agent, the formula also contain wetting agents (propylene glycol + polysorbate 80), buffering agent,...
23 December 2021 6,402 1 View
Can semi-synthetic drugs are also chemical drugs? Can we represent a semi-synthetic drug as a chemical drug?
22 December 2021 7,471 2 View
I have Cyclosporine drug product in ointment form. Cyclosporine is dissolve in most all organic . only Hexane has 5 mg/mL solubility. Insoluble in water. I can not use water because my drug...
20 December 2021 6,617 4 View
Hello everyone, I would like to ask if MONOACYLGLYCEROL LIPASE is a potential therapeutic target for research to find new drugs in the treatment of Alzheimer's disease?
19 December 2021 1,182 2 View
Why does combination therapy seem to be more effective for kidney cancer? Wouldn't you have more side effects due to consuming two drugs at the same time?
18 December 2021 7,598 3 View
Hi researchers, I was searching for the synergism of two different drugs by running mtt assay,I analyzed my data and I found them synergism, so I used each drug IC50 and both Ic50 to check them by...
18 December 2021 6,304 3 View
Please help explain with possible mechanisms with references for a better understanding.
18 December 2021 2,131 3 View
I am working with APTES and it has solid white particles in it. Is it expired or out of use? I am trying to modify mesoporous silica nanoparticles with APTES and it is not working. I have done...
18 December 2021 3,236 4 View
I have two treatments:1, breast cancer patients treated with drug A. 2, Breast cancer patients treated with Drug A+B. Each patient is either sensitive or resistant to drug A or Drug A+B. That...
17 December 2021 8,476 1 View
Hello everyone Is the MS/MS instrument capable of distinguishing between stereoisomers in general? if so, how? And, if I'm working on two stereoisomers drugs (E and Z), how can I separate them...
17 December 2021 315 5 View
According to Professor Colin Pouton's Lipid Formulation Classification System, when you incorporate an oil phase and and an water-insoluble surfactant, you are expected to get a Type II SEDDS. I...
16 December 2021 3,988 1 View
We PEGylated nanoparticles in DMSO with (5KDa PEG). Then we performed dialysis using a membrane of 3.5-5 kDa MWCO against DI water. Our nanoparticles has mol. wt. of 441 g/mol (441 Da) and size...
14 December 2021 5,747 12 View
Magnesium Sulphate is administered to pregnant women during preterm labour for fetal neuroprotection. Would like to know about any studies which have been done to evaluate its beneficial effects...
14 December 2021 144 7 View
I would like to count the macropinocytosis levels on MiaPaca-2 but I am a bit confused about the incubation time with the EIPA inhibitor and the Fitch-dextran. After I sees the cells and let...
14 December 2021 8,267 0 View
Dear all, I have been trying to extract protein from peripheral blood and bone marrow dry pellets. I have been using RIPA buffer, cOmplete protease inhibitor cocktail (Roche) and PMSF. When...
13 December 2021 773 2 View
Does it means that the precipitates are already present in the matrix or it tells information about overaging?in Al-Cu system
11 December 2021 4,225 11 View
I am trying to stimulate oral epithelial cells for cytokine release. I have tried different endotoxins, but not able to get any results. Any suggestions?
11 December 2021 1,682 2 View
Can we use AmberS99 for antibody (protein) and Charmm36 for antigen (drug like small non-protein) in md simulations? Or do we have to use only one forcefield for both?
08 December 2021 2,030 3 View