I made some solid dispersion samples with VAL (valsartan) as the active compound. I was expecting it to become amorphous form. However, when I first run it through DSC, the pure VAL drug has some peaks. On the other hand, one of the peaks of my solid dispersion sample has almost the same peak as the pure drug, just a bit broader. Also it has quite crowded peaks above the melting point of VAL. Could someone please help me?? Is it normal or what's the problem?:((
Thank you in advance🙏
@Jp Wu
Thank you for your response, can the ingredients composition affect that?
The crystalline form of valsartan that's used in the formula is 80% while the Polymer is only 20%.
In order to achieve stable ASDs, one should usually perform screening on excipients that can hold the most drug substance in ASD, then on compositional different ratios of drug substance to the selected most promisingly 2 or 3 your excipient candidates for further investigation.
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