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Questions related to Drugs
I am doing an MTT Assay of a new drug that I am experimenting with on MDAMB-231 Cells; however, I cannot figure out a dilution factor or an experimental setup on the MTT assay to see the IC50...
17 February 2022 2,173 5 View
When we get a poor 3d qsar model using SYBYL what are the steps to be followed to get a better 3d qasr model thank you
16 February 2022 4,449 8 View
If your drug, polymer and surfactant are soluble in same solvent and you are preparing nanoparticles of drug loaded into polymer and at the end of experiment you are getting clear solution. How...
15 February 2022 7,428 6 View
let me know details of the mechanism also
15 February 2022 8,135 3 View
We work on natural products to isolate some compounds that can be used as drugs. Does it also happen that while this type of research, new targets to treat that particular disease are...
14 February 2022 9,724 6 View
I use Propensity score matching for two different kinds of treatment (dummy and continuous treatment), which I will use each treatment in separate regression. So I converted the continuous...
14 February 2022 8,386 2 View
Regarding encapsulation efficiency (entrapment efficiency) test for Nanoparticles, If I'm targeting the detection of free drug in supernatant in order to estimate the percentage of drug entrapment...
13 February 2022 6,387 3 View
Dear researchers, Usually, the nucleophilic azidation can undergo with commercial available NaN3 with no further treatment. However, in some cases, the reaction requires NaN3 activated by...
12 February 2022 3,864 3 View
When a patient experiences complications due to an anti-psychotic drug that affects the heart rhythm, how do you deal with the patient in this case? Will you stop the anti-psychotic drug, which...
11 February 2022 6,050 3 View
So I'm pretty new to biochemistry and ELISA, and need to quantify estrogen/estradiol in rabbit serum. Does anyone have any advice on their most preferred estrogen ELISA kits for quantifying...
11 February 2022 4,743 1 View
Which API should be chosen for formulation development of Sotorasib tablets- Racemic mixture (mixture of enantiomer) or single isomer? Does therapeutic efficacy depend on enantiomeric form of...
10 February 2022 8,645 3 View
I am using RO-3306 CDK1 inhibitor drug to get IC50 and my cell lines is stops responding to to the drug and reach IC50 as previously, any suggestions? or other way to count cell death (I am using...
08 February 2022 2,294 2 View
I've calculated the proportion of active ingredients dissolved, but some of my results are ranging from well above 100%
08 February 2022 2,688 1 View
Hi, I am planning to conduct a clinical investigation as per ISO 14155:2020 for one of our products for which the target population is neonates. Our product is already commercially available on...
08 February 2022 2,341 6 View
I have done a calibration curve, from the absorbance values of a standard solution as a control. I have obtained my R2 values along with my y,m and c values. I also have absorbance values from my...
07 February 2022 8,964 3 View
I tested the toxicity of a drug in mice. I found increased collagen in the spleen. Can someone please share some paper to find out the reasons of this increased collagen deposition in the spleen....
07 February 2022 8,821 1 View
Hi all, I have a protein that needs to be purified with 0.05% Tween-20 in the buffer. My question is, can I concentrate this protein afterward with a centrifugal concentrator (10kDa)? I think...
07 February 2022 9,486 1 View
I am working on L. crispatus & L. acidophilus. After freeze-drying, I resuscitated the bacteria into MRD broth & left them in incubator at 37oC for 1 hour. After that, I performed cell...
06 February 2022 7,960 3 View
How to select mobile phase of HPTLC methods validation if drug pka value id 3.5 which factor we consider salection of mobile phases?
03 February 2022 7,272 4 View
Can anyone share ready made report templates for labsolutions shimadzu (postrun and browser)? Or tell me, please, where they can be found in the program itself or somewhere else. Thanks in advance.
01 February 2022 3,254 4 View
Please, has anyopne used CheckMateTwo-hybrid, Nanobit or Lumit from PROMEGA or PLA Duo Link from Sigma for studying protein interaction and discovery of drug inhibitor of the interaction?
31 January 2022 5,857 3 View
Need your suggestions regarding computational tools.
31 January 2022 1,609 13 View
Hi all, I am in desperate need of some basic stats help. I am looking at SF36 data for QOL between 2 groups (patient group and healthy group) at a single time point (cross-sectional design)....
31 January 2022 1,912 5 View
I know that 24, 48 and 72 are common but less than 24 hours is "allowed"? If my drug has some activity (low IC50) against some bacteria's strains in only 4 or 6 hours, is it enough to prove its...
27 January 2022 5,382 1 View