Clinical Pharmacology

Clinical Pharmacology and Clinical Therapeutics | Review and cite CLINICAL PHARMACOLOGY protocol, troubleshooting and other methodology information | Contact experts in CLINICAL PHARMACOLOGY to get answers

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Questions related to Clinical Pharmacology

Hello colleagues, can anyone explain what is the mechanism of action of antimicrobial agents extracted from marine algae on Fungi?

Hello colleagues, can anyone explain what is mechanism of action of antimicrobial agents extracted from marine algae on Fungi?

23 August 2020 953 8 View

How can you measure norepinephrine in frozen adipose tissue?

I would appreciate any suggestions on methodology to measure catecholamines in frozen adipose tissue. Any guidance is appreciated. Best, Molly

20 August 2020 1,525 2 View

Upto how many days can bacteria live without nutrition?

It is a very common established fact that bacterias can withstand long durations of deprived nutrition stages....a recent study diacover a microbe under sea bed which was almost 100 million in...

04 August 2020 5,449 15 View

When there is no melting peak observed in my DSC graph, how do I proceed to calculate the percentage crystallinity?

There is no melting peak observed for my DSC plot. How can I calculate percentage crystallinity of my sample. Sample material is PETG Thanks and regards, Vijayasanakr

02 August 2020 707 4 View

What positive control should I use?

Good afternoon everybody, I currently work on Liver Hepatocellular Carcinoma C3A cells. After Serum starving the cells, I would like to stimulate them with Serum media for 15 minutes and look at...

22 July 2020 5,413 0 View

I'm working on critical coagulation concentration(CCC) for several materials. Is there any theory based on CCC for molecular aggregations(not ionic)?

Is the Schulze-Hardy rule covers for the molecular coagulants, which can not be converted into ions in the solvent? Thank you for your information in advance.

18 July 2020 1,294 3 View

Is there any alternative of Chlorpyrifos for seedling root dip treatment in Rice ?

I need alternative of Chlorpyrifos for seedling root dip treatment in transplanted Rice.

12 July 2020 9,781 0 View

What are the challenges to finding an effective and consistent solution to the current threats and onslaught of COVID-19 (SARS-CoV-2)?

I think most known volunteers for the trial vaccines have died! Daily declared discovered cases were logged samples in the molicular labs that were just being tested, [slow process and few tests]...

02 July 2020 8,815 9 View

How to draw a ternary phase diagram for a complex elemental composition using FactSage?

I would like to draw a ternary phase diagram (TPD) for the biomass ash I am currently working on. However, the problem is its complex elemental composition. Previously, I have drawn TPDs for 3...

01 July 2020 4,599 7 View

How to use excel to analyze data that has more than 2 variables?

I am working on a project that is looking at antibody levels at different timepoints after administration of different vaccines in transplant patients. The variables that my PI wants me to plot...

29 June 2020 4,039 0 View

Doeas anyone has an experience in use MitoGraph software on Windows 8 or 10?

I would like to use MiroGraph software to analyze mitochondria's structure in fluorescence picture (stainde with mitoTracker) but it seems that this software is very unstable or it is not working...

29 June 2020 4,041 1 View

Is there any particular method to assess mitochondrial complex-III activity? What about MTT assay?

I would like to ask about a specific method for the determination of mitochondrial complex-III activity. There are reports of MTT assay as an indirect method for finding out mitochondrial...

28 June 2020 2,679 0 View

Refinement of NMR structure with RDC gives calculated RDC values always higher, than observed ones. What kind of mistake could it be?

I calculated protein solution structure by NMR and now I'm doing structure refinement using RDC. My RDC values are scattered from -22 to 15. I obtained tensor parameters using REDCAT program (Da...

27 June 2020 2,379 3 View

FTA card for RNA viurs?

Is it possible to extract HCV RNA from blood samples of HCV patients using an FTA card only without any commercial kit like QIAGEN RNA mini kit? According to the majority of literature, is this...

25 June 2020 7,657 0 View

Can someone help me with the objectives i can work on with End stage kidney disease patients compared to post transplant ones?

I am working with end stage renal patients together with post transplant ones. one of my objectives is to look at the hla polymorphisms in their loci to see frequencies in their alleles, just to...

21 June 2020 5,853 0 View

Does carbonization at lower temperature produces CNF with better quality than carbonization at higher temperature?

Thermal stabilization and carbonization are essential in obtaining fine electrospun CNF. Some articles report carbonization at quite lower temperature for different composites of the same parent...

19 June 2020 926 6 View

How to determine a domain substrate interaction?

Hi all, I just listened to a discussion about protein domains and a potential substrate binding. A question was given and I was thinking how to tackle the problem. Let's say: a functional protein...

19 June 2020 1,424 0 View

What is the best route to follow during the electrospinning of chitosan?

I am currently doing a theoretical research on the electrospinning of chitosan. As a result of my research, I found out that there are too many parameters that affect the process (Molecular weight...

18 June 2020 4,405 0 View

Is it feasible to culture human PBMC after RBC Lysis ?

Hi all, for a project, I would like to perform RBC Lysis of human whole blood and then put the cells in culture with PHA for 3 days prior to flow cytometry analysis, gating mainly on T...

11 June 2020 8,645 1 View

Please tell me the technique which i can use to estimate each cross section separately in panel data model?

Provided that the issue of endogeneity is also present in the model.

29 May 2020 856 0 View

Increase the stability of tetrode recordings by application of immunosuppressives?

In some publications I have read about the use of immunosuppressive drugs and antibiotics directly during surgery to prevent inflammation and brain swelling (e.g. dexamethasone and enrofloxacin in...

21 May 2020 9,489 0 View

Is it better to compare AUC or IC50 values against Protein Expression Data?

I'm using the proteomics data set from DepMap and I have the AUC and IC50 values for compounds from GDSC...what is the best method to compare? I used AUC and relative protein expression to...

20 May 2020 8,803 0 View

How to segment the selera and iris to calculate area using ImageJ?

I am having difficulty segmenting the selera and iris from the rest of the background (skin,eyelashes etc.) to calculate the area using the threshold tool. I had also tried freehand selection...

19 May 2020 8,533 0 View

Is endovascular cooling able to trigger contraction of intracranial aneurysmal walls as a potential treatment?

This is going to work differently from clipping and coiling, making use of temperature variable as a therapeutic target. Input much appreciated!

19 May 2020 2,736 0 View

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