Clinical Pharmacology

Clinical Pharmacology and Clinical Therapeutics | Review and cite CLINICAL PHARMACOLOGY protocol, troubleshooting and other methodology information | Contact experts in CLINICAL PHARMACOLOGY to get answers

2,034 views 1,483 posts

Questions related to Clinical Pharmacology

There is some variant of intracellular solution for patch clamp without GTP?

Hello! Some of you could to tell me if there is any recipe to prepare intracellular solution based on K-gluconate that does not cointain GTP? Thank U

28 February 2020 1,689 4 View

Why I am getting different interactions in model protein ??

I have modeled a protein that has 71% similarity and 60% identity to the template but when I visualized and compared I got slight change in interactions although the residue is same and...

11 February 2020 8,142 0 View

How can we estimate the spectrin dimers and spectrin tetramers in Red blood cells?

Spectrin is crucial for maintaining the stability and structure of the cell membrane and the shape of a Red blood cells.

07 February 2020 5,435 2 View

How to generate of hypomorphic mouse?

I am studying some protein which is lethal in utero when knocked out. I read some paper about so called "hypomorphic mouse" such as for klotho or GTPCH1 protein. Does anyone know how to generate...

30 January 2020 8,133 0 View

How do Ketamine and xylazine work?

Want to know. I appreciate if anyone can answer.

27 January 2020 3,881 2 View

Pharmacy Practice was always clinical, taking care of patients, but why it is considered by some as non-clinical?

Read more about it and give me your opinion; Dixon Thomas' book Clinical Pharmacy Education, Practice and...

25 January 2020 5,298 4 View

Does it require testing each topical formulation of our drug in laboratory animals, if drug has showed potential at some concentrations?

We have evaluated the wound healing potentials of a compound at a particular concentration in ointment form in laboratory animals. Now, we are preparing different types of topical formulations...

15 January 2020 3,100 6 View

Is a portable analyzer suitable for Sphagnum (peat moss)?

In vascular plant, the portable chlorophyll meter (such as CCM-200 or SPAD 502PDL) is widely used to estimated Chlorophyll content. In moss, Varela (2013) used the chlorophyll meter to...

04 January 2020 3,702 3 View

Can you describe your thermal comfort sensation now (this winter for North hemisphere and summer for south hemisphere)?

Please complete this questionnaire Name: Age: Office type: Open space office/closed office HVAC system: Yes/No Natural ventilated NV: Yes/No Season: Winter/Summer Climate...

02 January 2020 1,310 15 View

What is the optimal start up sequence of three series pumps?

Dear all, Suppose that three crude oil products transmission elector-pumps are installed in series mood in a pump station. The pump station operator want to operate the elector-pumps. He/She can...

17 December 2019 7,513 0 View

Migraine/cluster headaches are caused by vasodilation, then how do Verapamil (Vasodilator) work in it's managment ?

Verapamil, A calcium channel blocker is used for prophylaxis of cluster headache. Verapamil is a vasodilator. What is its mechanism in preventing headache ?

20 November 2019 7,613 4 View

Best way for h.pylori isolation?

i'am working on Helicobacter pylori and i'm trying to get a pure colony but it's too difficult! i wanna know the best sample and conditions for bacteriological isolation of H.pylori.

01 November 2019 5,788 4 View

Dear Collegues, are cell membrane fluctuations of any interest for you within scole of your project?

it may be that cell membrane fluctuations can either promote or suppress apoptosis. and may be erythrocyte can survive in the absence of growth factors. will You pay attention to possible(!)...

29 October 2019 6,040 2 View

What kind of modification process of bentonite should be used to prepare a bentonite-based coagulant for paint detackification?

Dear colleagues, I‘m trying to modify a sodium bentonite to make it capable of coagulation (detackification) of solvent borne paint in water. The goal is to produce a product from conventional...

10 October 2019 4,243 0 View

About the rabbit model of chronic dry eye disease Induced by Complete Surgical Dacryoadenectomy methods?

Hi, this is Chang from National Taiwan University. Regarding the paper ‘’A New Rabbit Model of Chronic Dry Eye Disease Induced by Complete Surgical Dacryoadenectomy’’. (2019, VOL. 44, NO. 8,...

24 September 2019 9,805 0 View

About the Rabbit Complete Surgical Dacryoadenectomy methods?

High, this is Chang from National Taiwan University, Regarding the paper ''A New Rabbit Model of Chronic Dry Eye Disease Induced by Complete Surgical Dacryoadenectomy '' I am wondering about the...

24 September 2019 9,638 0 View

How to interpret the results of LSTM model for detection of Myocardial infarction on ECG?

hi, i am using LSTM for detection of Myocardial infarction using physionet PTB diagnostic ECG data. this database have 294 patients within it of which there is 148 patients with MI and 52 of...

17 September 2019 8,511 0 View

How to develop WHHL rabbit model for Coronary Heart Disease Study?

Hello altruits! Does anyone have a protocol on how to house and treat WHHL rabbits for CHD? I have searched and consulted handful of literature to find out the diet to use for this model, but...

08 September 2019 1,373 0 View

Is EC50 or EC80 concentraion of a ligand from a direct binding assay the better choice to establish a competitive assay as the next step?

The norm with most assays such as FP has been to use EC80, however with MST, the manual suggests different versions! Though it is simpler to establish a competition with EC50 concentration in...

03 September 2019 7,341 0 View

How ketamine helps in status asthmatics ?

Status asthmatics is very difficult to treat and can be very challenging to treat. Whats the MOA of ketamine in this condition.

26 August 2019 6,967 3 View

What is the indirect markers of oxidative stress?

Dear colleagues; Are reduced glutathione (GSH), uric acid, and vitamin C biomarkers for oxidative stress in biological systems? Please, provide your answer with reference/s Regards

13 August 2019 2,794 7 View

Toxicity assay not working in ES cells, help?

Dear all, I have human ES cells, I have been exposing them to chemicals like aspirin, amiodarone, chlorpheniramine, chlorpromazine, clotrimazole, 2,4-dinitrotoluene, ibuprofen etc. The cells just...

08 August 2019 7,512 0 View

Minimal Media for Staphylococcus aureus?

I am trying to culture staphylococcus aureus in minimal media. So far I have tried DMM, M9 and M63 minimal media which has a carbon source as either glucose or glycerol. Nitrogen source as...

30 July 2019 8,561 4 View

How to filter a noisy signal coming out of an accelerometer?

hi , i need a filter for the noisy signal obtained from the accelerometer in drop weight tear test. adore your help.

11 July 2019 3,836 0 View

Badges
Science topic