Clinical Pharmacology and Clinical Therapeutics | Review and cite CLINICAL PHARMACOLOGY protocol, troubleshooting and other methodology information | Contact experts in CLINICAL PHARMACOLOGY to get answers
24 views 182 posts
Questions related to Clinical Pharmacology
I think most known volunteers for the trial vaccines have died! Daily declared discovered cases were logged samples in the molicular labs that were just being tested, [slow process and few tests]...
01 July 2020 8,471 9 View
Hi everyone, I wonder if someone has ever used osmotic mini-pump for an escalating dose regimen. I read that some iPRECIO osmotic mini-pump are programmable and therefore can be used for infusion...
03 April 2020 8,973 3 View
how H CQ+Azi acts against covid 19?
31 March 2020 4,006 9 View
We have evaluated the wound healing potentials of a compound at a particular concentration in ointment form in laboratory animals. Now, we are preparing different types of topical formulations...
14 January 2020 2,846 6 View
Verapamil, A calcium channel blocker is used for prophylaxis of cluster headache. Verapamil is a vasodilator. What is its mechanism in preventing headache ?
19 November 2019 7,389 4 View
I am in doubt about different methods of preparations and calculations. While I performed it I got turbid material after denaturation by heating at 57 C for 3 minutes. So the absorbance at 416 nm...
31 August 2018 8,189 1 View
I have dissociation constant (Kd) for a drug- receptor complex. Can I calculate the minimum effective conc. (MEC) using this Kd? How also can I calculate the oral dose that will cause this MEC or Kd?
20 July 2018 670 3 View
Is it after reaching the steady state concentration (3-5days) or it may take more days to reach the maximum effect for atrial fibrillation control?
19 April 2018 1,129 11 View
Aren't we suppose to see the peak effect after 4-5 half lives of the drug? After reaching the Css? I did view the drug monograph, and it states that the peak effect is seen after 6 hrs not after...
05 April 2018 7,006 7 View
Although cancer immunotherapy can be quite effective, it has a variety of drawbacks.
27 February 2018 6,710 19 View
It is recommended in some references to avoid the combination of metronidazole & mebendazole as the risk of steven johnson's syndrome is increased. 1-are there any statistics reg the...
27 February 2018 1,565 9 View
Inflammation and reactive oxygen species (ROS) production after central nervous system injury. What about the cancer? https://www.nature.com/articles/s41556-018-0048-9.pdf
25 February 2018 5,363 1 View
Which agent is the best for occasional use for someone who has NAFLD ? and why ?
22 February 2018 9,374 15 View
I have TTX citrate ordered from Hello Bio. On using it at 1uM as my working concentration, it didn't show any effect. How do I test whether the toxin is actually working or not?
16 February 2018 825 4 View
There are contradictory data, two references are attached. What would be your decision ? Recommend it or not ?
16 February 2018 5,030 6 View
Isn't Css the same as the plasma therapeutic level ? Because if so, in the case of Acetaminophen, just one dose of 500 mg would reach the Css, and there would be no need for 4-5 half life ? if...
10 February 2018 3,753 4 View
Do all drugs need to achieve the steady state concentration after 4-5 half life in order to see the therapeutic effect ? Doesn't ibuprofen produce its effect from a single dose without 4-5 half...
06 February 2018 7,117 17 View
Take this example (Bisoprolol is the mentioned example ) : assuming that 5 mg is the minimum effective dose dosing with 5 to 20 mg, and mean peak values range from 16 ng/mL at 5 mg to 70 ng/mL...
06 February 2018 4,151 3 View
I have researched, and there are many available ways to manage cough in community pharmacy setting, so which resource or reference do you use ?
27 January 2018 2,888 12 View
I have researched, and they are used interchangeably, so I'd like to know if there is any paper or article that can illustrate the difference between both on the molecular or cellular level ?
24 January 2018 1,486 3 View
Is it just you go check graded dose response curve for comparing different pharmaceutical agent ? Or there is another fast quick method ? Lets say you want to give the most available otc analgesic...
06 January 2018 5,307 9 View
In this scenario, I'm interested in Daflon (Trade name). Could misdiagnosis be harmful and turn the Pharmacological and therapeutic effect of a drug (Daflon) into an adverse reaction? We know that...
31 December 2017 9,312 2 View
I'd like to know how far should I go with regard to the effect? For example, we know that bisoprolol reduce the heart rate, so, lets assume this is the only known effect that has been shown...
12 December 2017 6,646 8 View