Clinical Pharmacology

Clinical Pharmacology and Clinical Therapeutics | Review and cite CLINICAL PHARMACOLOGY protocol, troubleshooting and other methodology information | Contact experts in CLINICAL PHARMACOLOGY to get answers

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Questions related to Clinical Pharmacology

What are the challenges to finding an effective and consistent solution to the current threats and onslaught of COVID-19 (SARS-CoV-2)?

I think most known volunteers for the trial vaccines have died! Daily declared discovered cases were logged samples in the molicular labs that were just being tested, [slow process and few tests]...

02 July 2020 8,669 9 View

Escalating dose regimen with osmotic mini pump?

Hi everyone, I wonder if someone has ever used osmotic mini-pump for an escalating dose regimen. I read that some iPRECIO osmotic mini-pump are programmable and therefore can be used for infusion...

04 April 2020 9,166 3 View

What is the mechanism of action of HCQ+Azi against covid 19 infection?

how H CQ+Azi acts against covid 19?

01 April 2020 4,195 9 View

Does it require testing each topical formulation of our drug in laboratory animals, if drug has showed potential at some concentrations?

We have evaluated the wound healing potentials of a compound at a particular concentration in ointment form in laboratory animals. Now, we are preparing different types of topical formulations...

15 January 2020 3,059 6 View

Migraine/cluster headaches are caused by vasodilation, then how do Verapamil (Vasodilator) work in it's managment ?

Verapamil, A calcium channel blocker is used for prophylaxis of cluster headache. Verapamil is a vasodilator. What is its mechanism in preventing headache ?

20 November 2019 7,585 4 View

Hi, which is the proper method for the inhibition of protein (albumin fraction) denaturation by plant extracts?

I am in doubt about different methods of preparations and calculations. While I performed it I got turbid material after denaturation by heating at 57 C for 3 minutes. So the absorbance at 416 nm...

01 September 2018 8,352 1 View

How can I calculate minimum effective conc. if I have dissociation constant ?

I have dissociation constant (Kd) for a drug- receptor complex. Can I calculate the minimum effective conc. (MEC) using this Kd? How also can I calculate the oral dose that will cause this MEC or Kd?

21 July 2018 840 3 View

How much time does Flecainide take to reach its maximum "peak effect"?

Is it after reaching the steady state concentration (3-5days) or it may take more days to reach the maximum effect for atrial fibrillation control?

20 April 2018 1,303 11 View

How is the peak effect of Lisinopril is after 6 hrs?

Aren't we suppose to see the peak effect after 4-5 half lives of the drug? After reaching the Css? I did view the drug monograph, and it states that the peak effect is seen after 6 hrs not after...

06 April 2018 7,195 7 View

What are the main drawbacks of cancer immunotherapy?

Although cancer immunotherapy can be quite effective, it has a variety of drawbacks.

28 February 2018 6,903 19 View

Are Metronidazole/mebendazole contraindicated together?

It is recommended in some references to avoid the combination of metronidazole & mebendazole as the risk of steven johnson's syndrome is increased. 1-are there any statistics reg the...

28 February 2018 1,726 9 View

Nature news: Exosomes deliver ROS for regeneration. I wonder, Is that also true for cancer?

Inflammation and reactive oxygen species (ROS) production after central nervous system injury. What about the cancer? https://www.nature.com/articles/s41556-018-0048-9.pdf

26 February 2018 5,531 1 View

Acetaminophen or Aspirin or Ibuprofen for headache for someone who has NAFLD for occassional use ?

Which agent is the best for occasional use for someone who has NAFLD ? and why ?

23 February 2018 9,542 15 View

How do I confirm whether Tetrodotoxin citrate is working or not?

I have TTX citrate ordered from Hello Bio. On using it at 1uM as my working concentration, it didn't show any effect. How do I test whether the toxin is actually working or not?

17 February 2018 983 4 View

Is Enalapril safe for lactating women ?

There are contradictory data, two references are attached. What would be your decision ? Recommend it or not ?

17 February 2018 5,223 6 View

Isn't Css the same as the plasma therapeutic level ?

Isn't Css the same as the plasma therapeutic level ? Because if so, in the case of Acetaminophen, just one dose of 500 mg would reach the Css, and there would be no need for 4-5 half life ? if...

11 February 2018 3,936 4 View

This is confusing! Which drugs need to achieve steady state concentration in order to see the effect ?

Do all drugs need to achieve the steady state concentration after 4-5 half life in order to see the therapeutic effect ? Doesn't ibuprofen produce its effect from a single dose without 4-5 half...

07 February 2018 7,299 17 View

How does the MEC corresponds to minimum effective dose although they aren't the same ?

Take this example (Bisoprolol is the mentioned example ) : assuming that 5 mg is the minimum effective dose dosing with 5 to 20 mg, and mean peak values range from 16 ng/mL at 5 mg to 70 ng/mL...

07 February 2018 4,324 3 View

Which guidelines/resource do you use to manage patients with cough in community pharmacy setting ?

I have researched, and there are many available ways to manage cough in community pharmacy setting, so which resource or reference do you use ?

28 January 2018 3,061 12 View

May someone point me to a resource to illustrate the difference between nasal congestion and rhinorrhea ?

I have researched, and they are used interchangeably, so I'd like to know if there is any paper or article that can illustrate the difference between both on the molecular or cellular level ?

25 January 2018 1,656 3 View

In practice, how do you know which pharmaceutical agent is more efficacious ? Is it just you go check graded dose response curve ?

Is it just you go check graded dose response curve for comparing different pharmaceutical agent ? Or there is another fast quick method ? Lets say you want to give the most available otc analgesic...

07 January 2018 5,474 9 View

Could the Pharmacological effect turn into adverse reaction in case of misdiagnosis ?

In this scenario, I'm interested in Daflon (Trade name). Could misdiagnosis be harmful and turn the Pharmacological and therapeutic effect of a drug (Daflon) into an adverse reaction? We know that...

01 January 2018 9,476 2 View

How far should I go with regard to the therapeutic effect ?

I'd like to know how far should I go with regard to the effect? For example, we know that bisoprolol reduce the heart rate, so, lets assume this is the only known effect that has been shown...

13 December 2017 6,810 8 View

Postmenopausal osteoporosis problem ?

55 year old Caucasian woman not obese has the symptoms of osteoporosis. Her doctor prescribed a large dose of ca with different formulas and vitamen D3 . Weeks after starting the medicines...

24 October 2017 799 9 View

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