Clinical Pharmacology

Clinical Pharmacology and Clinical Therapeutics | Review and cite CLINICAL PHARMACOLOGY protocol, troubleshooting and other methodology information | Contact experts in CLINICAL PHARMACOLOGY to get answers

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Questions related to Clinical Pharmacology

Can HBsAg clear after treatment of chronic hepatitis B?

Persistence of Hepatitis B surface antigen (HBsAg) in the serum is one of the defining features of chronic hepatitis B. Regardless of the exact phase and the eligibility for treatment, many...

19 May 2021 5,194 9 View

Raman spectral resolution versus the minimum shifting in the Raman peaks?

Raman spectral resolution of 1.65 cm^-1 is obtained while using the 600 lines per mm grating in the spectrometer; in this condition can we compare and analyze the Raman peak shifting trends with...

19 May 2021 2,438 10 View

Anyone has experience in culturing PBMCs and activating them with T cell transact?

Good morning, I am going to start culturing PBMCs with TexMacs Medium, T cell transact and IL-2 (30 IU/ml). Anyone has tricks and tips about this process or has ever tried it with the t cell...

03 May 2021 5,604 0 View

What is the reason that walnut leaves cut from stem and fallen on ground in night as shown in clip?

All the walnut researchers kindly watch the clip and suggest the remedial measure as the leaves of walnut tree cut down from stem and found fallen on ground in morning. This clip is from Doda area...

26 April 2021 8,244 3 View

Why tetracycline is bacteriostatic and aminoglycoside is bactericidal although both act through inhibition of bacterial protein synthesis?

Please illustrate the cause

14 April 2021 4,452 2 View

If the Bacterial cells (not exposed) to any type of Antibiotics, does gene expression of the genes related to Antibiotic resistance occur ??

resistance antibiotic

11 April 2021 8,383 7 View

How can I set femtosecond laser pump in Time Domain?

Hello brothers, I try to build a Photoconductive Antenna.. I tried to set a femtosecond laser pump in Time Domain... This laser hits the gap between electrodes..Then we will get a Terahertz...

06 April 2021 1,386 0 View

How does nitrous oxide (works as antagonist at NMDA receptor) make the brain more susceptible to acoustic entrainment using binaural beats?

How does nitrous oxide (works as antagonist at NMDA receptor) make the brain more susceptible to acoustic entertainment using binaural beats? thanks

05 April 2021 6,053 0 View

What can tears contain that could be a possible biomarker for Glaucoma?

We have this proposal to use immunochromatography, or lateral flow assay test, to detect Glaucoma. After doing some related literature search, I found an article suggesting tears as a great...

01 April 2021 3,359 3 View

How do I analyze valine flux by bacillus subtilis on optflux?

I'm a begginer in optflux and when I do the simulation of wild type of bacillus subtilis, I can't find the data of the branched amino acids production. I think that's because the reaction of...

01 April 2021 2,224 0 View

What to use: Anesthesia for bone marrow transplantation in mice ?

Could anyone recommend the appropriate anesthetic procedure for BMT in mice? I do bone marrow transplantation in mice as a part of my study. The problem is, the engraftment rate got pretty low...

27 March 2021 9,732 5 View

What are the conditions for relaminarization?

Hi, I am trying to find about conditions related to relaminarization of fluid flow both in liquid and gases. In this regard, I would like to know if there are any theoretical or empirical...

25 March 2021 6,393 8 View

Hydrazine vs Hydrazine Hydrate for chalcogenide solution ?

Can anyone tell if there is any difference between the solubility of various chalcogenides in hydrazine and hydrazine hydrate (HH)? All reported solution-processed chalcogenides are dissolved in...

19 March 2021 8,887 1 View

How can I continue my research project in PhD?

My research article is " Development and validation HPLC method for simultaneous determination of dexamethasone sodium phosphate and prednisolone acetate I Injectable Veterinary Suspension " in...

17 March 2021 6,222 0 View

Does trace of blood in acute pyelonephritis most likely contribute to the reagent strip protein result of30 mg/dL?

A 30-year-old woman is seen by her physician. She has a temperature of 101°F and reports nausea and headache, with flank (below ribs and above iliac crest) tenderness and pain. When asked, she...

02 March 2021 2,199 2 View

How to properly perform a DPPH antioxidant activity analysis for active ingredient-loaded micelles?

Dear colleagues and academics, For the research work we're conducting, we have synthesized active ingredient-loaded polymeric micelles. After finding the best formulation and preparing a big...

22 February 2021 9,533 5 View

What could lead to multiple enzymes not cutting DNA?

We have isolated Phage DNA with the Qaigen Phage DNA Isolation Kit. Those samples were treated multiple times with various enzymes. We have done single, double, and triple digests to no avail. We...

16 February 2021 6,050 7 View

Which assays for measuring cell viability/cytotoxicity of Caco-2 cells upon bacterial infection?

Hi all, I am currently working on an infection experiment with Caco-2 cells and bacteria and would like to measure cell viability and cytotoxicity of the Caco-2 cells after infection. Since...

15 February 2021 3,856 4 View

Can anyone suggest a protocol to isolate exosome from saliva (without a kit)?

Hi, I need to isolate some exosomes from saliva. Any way of doing this without a kit?

10 February 2021 1,227 7 View

Which protocol can I use to assess the behavior of ornamental fish during and after anesthesia?

Using eugenol to anesthetize freshwater angelfish (Pterophyllum scalare), behavior is apparently affected not only during anesthesia, but also after anesthesia. The study by Cooke et al. (2004) is...

09 February 2021 3,035 2 View

In cluster analysis, which formula is most relevant for reducing the spatial relationships between about 26 points on a hemisphere?

Structuralist anthropology had reduced some aspects of culture to equations (Levi-Strauss, updated by James Harrod, discussed in my paper Blueprint). The spatial layer of nature and culture...

03 February 2021 3,701 0 View

What are potential mitochondria protecting drugs for ALS?

Research has shown that mitochondria protecting agents could offer theraputic benefits in ALS. I am looking for suggestions on which ones, already used in humans, would be good candidates for...

30 January 2021 630 5 View

How can I estimate QALYs in Arena (Simulation Software)?

Hi, I am trying to assign patients QALYs before they receive a transplant. My model looks like this: a create module (patients arrive waiting list), a delay module (patients wait for transplant)...

29 January 2021 9,692 1 View

Knocking in small tags at endogenous loci in mouse ES cells?

Hello, I am trying to find a minimal length of homology arms required to knock in small tags in the mouse ES cells. My tag is 207 bp long and wondering I need to have long homology arms. Plus, I...

29 January 2021 4,966 0 View

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