Clinical Pharmacology

Clinical Pharmacology and Clinical Therapeutics | Review and cite CLINICAL PHARMACOLOGY protocol, troubleshooting and other methodology information | Contact experts in CLINICAL PHARMACOLOGY to get answers

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Questions related to Clinical Pharmacology

How many polysaccharides are present in 62 kDa of LMW chitosan?

For Low Molecular Weight (LMW) chitosan, the molecular weight is 50,000 to 100,000 Da.

02 July 2019 7,161 2 View

What is the best technique to bleed mice after xylazine/ketamine overdose?

I started in a lab fairly recently that uses lots of blood/serum for assays. When each study is terminated, the mice are given a lethal dose of xylazine and ketamine and then opened up for...

27 June 2019 8,102 0 View

Kindly share literature and your experience on use of accelerated protocol of rTMS for treating OCD?

How beneficial is the accelerated protocols of rTMS in management of OCD?

22 June 2019 8,905 5 View

What is the most effective treatment for OCD?

21 June 2019 1,059 21 View

Does anybody know any vitamin D receptor antagonist available in the market?

Hello, Although there are several papers using vitamin D antagonist like TEI-9647, none these products seem to be available in the market. I was wondering if anybody know any vitamin D receptor...

12 June 2019 1,917 1 View

Can anyone recommend liquid media and any supplementation that they have used, for carrot callus please?

I have several published ideas but would like to hear from those who have personal experience that may provide helpful tips.

11 June 2019 6,876 0 View

Ketamine/xylazine cocktail dose for Thy1-Chr2-YFP mice?

I am using a cocktail of 1ml ketamine, 0.5 ml Xylazine and 8.5 of saline, to anesthetize Thy1 transgenic mice. Lately the anesthesia doesn't seem to work properly, and I spend a lot of time to...

30 May 2019 9,068 3 View

Is stretching an effective method to prevent sarcopenia?

As stretching i) involves lower perceived exertion and energy expenditure, but ii) stimulates protein synthesis, could it be used as a method to attenuate the loss of muscle mass in elderly...

25 May 2019 2,642 5 View

How to calculate molecular weight of monomeric unit of phthalated chitosan??

How to calculate the molecular weight of monomeric unit of phthalated chitosan if the degree of deacetylation for chitosan was 80% and degree of substitution for phthalated chitosan was 12 %.

21 May 2019 4,637 2 View

What should an ideal prescription for diabetic foot care include in terms of Ayurveda as well as Modern as well as integrative therapy?

Different clinical methods are being practiced for Diabetic foot care. Success ratio, recurrence and failure rates are different at their levels. This question is to discuss important points in...

21 May 2019 2,848 8 View

Is there any study, that evaluated early augmentation role of TMS in OCD?

Early augmentation with TMS refers to: Augmenting SSRIs /SNRIs / Clomipramine with TMS early in the course of treatment (may be in the first week of treatment initiation) OR CBT (alone)...

06 May 2019 8,147 2 View

In general what will be the BNF in rice, maize, groundnut, pigeon pea, greengram, cotton, sweetcorn, fodder per ha.?

what will be BNF in kg per ha. in rice crop in general (without any addition of biofertilizers in field)

06 May 2019 8,161 2 View

Please guide what does below mentioned r2 values fmo my genotyping study indicate? -308/238 TNF SNP r2=0.076 (for patients) and r2= 0.11(for control)?

Dear All, I have been working with TNF alpha (-308/-238)and Resistin (-420/+299) SNPs. One of thesis reviewer has asked me to mentioned r2 values for TNF alpha (-308/-238) and Resistin...

25 April 2019 5,374 0 View

Is this pcr product is good enough to do digestion by restriction enzyme?

This is the result of the pcr experiments of some samples, I want to know if it good enough to digest it by RE to detect polymorphism or I should perform PCR again. Also I want to know if...

22 April 2019 201 0 View

What is the way to measure grain loss in the head of combine harvester ?

we want to measure grain loss in the head of combine harvester when combine is harvesting products with high head loss like canola, cotton,... . I want to know what is the best way to measure it.

21 April 2019 6,924 4 View

How to stain the Acetylcholinesterase and the Cholin-acetyltransferase in NMJ of mouse diaphragm?

I try to stain the Acetylcholinesterase and the Cholin-acetyltransferase in neuromuscular junction of diaphragm of mice with ALS model. I use abcam antybodies - Anti-Acetylcholinesterase antibody...

20 April 2019 7,659 2 View

Why ketamine/xylazine in mice is not working?

In my postdoc I always used the anesthesic protocol of ketamine(80mg/kg)/xylazine (10mg/kg) injecting 0,1ml ip for balb-c mice. And it works very well. However now using Swiss mice from another...

15 April 2019 706 5 View

Reasrch Topic on hospital management closely related to dermatology discipline?

ًHello! I hope Someone will help me for selection of a reasrch topic on hospital management closely related to dermatology discipline?

15 April 2019 3,214 3 View

How to fix bacteria for MEB Analysis ?

Hi all, I want to exhibit antimicrobial activity of silver nanoparticles against bacteria E.coli and Staphylococcus aureus . I have prepared samples of silver- bacteria using glycerol (dispersed...

14 April 2019 8,773 3 View

Is there a salivary stimulant that does not interfere with cortisol, melatonin and serotonin assays, and does not alter glucose levels?

This is for a research protocol in spider monkeys' chronobiology. So far the best saliva extracting device has been an aspirator that allows collecting about 1 ml in 2-8 min. The issue is that...

28 March 2019 6,507 1 View

What is different in Immune Response in Pregnant Women Infected with Acute Vaginal Abscess Caused by Staphylococcus Aureus and Trichomonas Vaginalis?

Vaginal abscess in pregnant women caused by Staphylococcus aureus and Trichomonas vaginalis is one of the most important disease, this infection is still medically uncontrolled because of poor...

15 March 2019 5,867 6 View

Could latest antidepressant agent Esketamine be a decisive turning point in MDD treatment?

The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce a rapid antidepressant effect...

13 March 2019 7,622 14 View

What are models used in ca channel blockers in neuromuscular junction?

I synthesise the novel derivatives. I want test them on such junction model.

12 March 2019 8,566 0 View

How to find exact d-spacing from HRTEM using digital micro-graph software? Such as mentioned in attached figure?

11 March 2019 2,364 3 View

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