Clinical Pharmacology

Clinical Pharmacology and Clinical Therapeutics | Review and cite CLINICAL PHARMACOLOGY protocol, troubleshooting and other methodology information | Contact experts in CLINICAL PHARMACOLOGY to get answers

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Questions related to Clinical Pharmacology

How useful are broad-spectrum phospho serine antibodies?

I have a question about universal phospho serine antibodies. My protein of interest is phosphorylated at six sites. All serines. Would it be more elegant to do an IP with my target and then use a...

21 June 2021 9,589 0 View

How long can I keep Carvedilol dissolved in DMSO in 4 degrees?

I need to store my extra carvedilol. However, I could not find this information in literature. Could you help me? Thank you.

16 June 2021 8,074 3 View

Why FDA approved nasal spray of (S)-ketamine for treatment-resistant depression instead of (R)-ketamine in 2019?

I have read some articles mostly in which (R)-ketamine was revealed as a safer antidepressant with more efficacy than (R, S)-ketamine and (S)-ketamine. Hence, my question is why FDA approved nasal...

13 June 2021 8,894 6 View

How can I add Sulphuric acid or Sodium bicarbonate in PHT3D with GMS?

I want to do simulation of Insitu leaching system by using PHT3D with GMS as GUI. But during Input of species I can't find sulphuric acid or ammonium bicarbonate in wateq4f database nor in phreeqc...

06 June 2021 6,553 0 View

Are there for suggestions for house-keeping genes for porcine vaginal epithelium expression besides GAPDH?

I've working on trouble shooting qPCR within my lab on some porcine vaginal samples. I converted the RNA to cDNA and selected two house-keeping genes (B-actin and GAPDH), based on previously...

20 May 2021 2,535 1 View

Can HBsAg clear after treatment of chronic hepatitis B?

Persistence of Hepatitis B surface antigen (HBsAg) in the serum is one of the defining features of chronic hepatitis B. Regardless of the exact phase and the eligibility for treatment, many...

19 May 2021 5,131 9 View

Anyone has experience in culturing PBMCs and activating them with T cell transact?

Good morning, I am going to start culturing PBMCs with TexMacs Medium, T cell transact and IL-2 (30 IU/ml). Anyone has tricks and tips about this process or has ever tried it with the t cell...

03 May 2021 5,549 0 View

Why tetracycline is bacteriostatic and aminoglycoside is bactericidal although both act through inhibition of bacterial protein synthesis?

Please illustrate the cause

14 April 2021 4,386 2 View

If the Bacterial cells (not exposed) to any type of Antibiotics, does gene expression of the genes related to Antibiotic resistance occur ??

resistance antibiotic

11 April 2021 8,315 7 View

How does nitrous oxide (works as antagonist at NMDA receptor) make the brain more susceptible to acoustic entrainment using binaural beats?

How does nitrous oxide (works as antagonist at NMDA receptor) make the brain more susceptible to acoustic entertainment using binaural beats? thanks

05 April 2021 6,000 0 View

What to use: Anesthesia for bone marrow transplantation in mice ?

Could anyone recommend the appropriate anesthetic procedure for BMT in mice? I do bone marrow transplantation in mice as a part of my study. The problem is, the engraftment rate got pretty low...

27 March 2021 9,667 5 View

Hydrazine vs Hydrazine Hydrate for chalcogenide solution ?

Can anyone tell if there is any difference between the solubility of various chalcogenides in hydrazine and hydrazine hydrate (HH)? All reported solution-processed chalcogenides are dissolved in...

19 March 2021 8,829 1 View

How can I continue my research project in PhD?

My research article is " Development and validation HPLC method for simultaneous determination of dexamethasone sodium phosphate and prednisolone acetate I Injectable Veterinary Suspension " in...

17 March 2021 6,157 0 View

Does trace of blood in acute pyelonephritis most likely contribute to the reagent strip protein result of30 mg/dL?

A 30-year-old woman is seen by her physician. She has a temperature of 101°F and reports nausea and headache, with flank (below ribs and above iliac crest) tenderness and pain. When asked, she...

02 March 2021 2,115 2 View

Which assays for measuring cell viability/cytotoxicity of Caco-2 cells upon bacterial infection?

Hi all, I am currently working on an infection experiment with Caco-2 cells and bacteria and would like to measure cell viability and cytotoxicity of the Caco-2 cells after infection. Since...

15 February 2021 3,796 4 View

Which protocol can I use to assess the behavior of ornamental fish during and after anesthesia?

Using eugenol to anesthetize freshwater angelfish (Pterophyllum scalare), behavior is apparently affected not only during anesthesia, but also after anesthesia. The study by Cooke et al. (2004) is...

09 February 2021 2,969 2 View

What are potential mitochondria protecting drugs for ALS?

Research has shown that mitochondria protecting agents could offer theraputic benefits in ALS. I am looking for suggestions on which ones, already used in humans, would be good candidates for...

30 January 2021 577 5 View

How can I estimate QALYs in Arena (Simulation Software)?

Hi, I am trying to assign patients QALYs before they receive a transplant. My model looks like this: a create module (patients arrive waiting list), a delay module (patients wait for transplant)...

29 January 2021 9,640 1 View

Is there any association between anaemia and vaginal candidiasis?

I would like to know about studies regarding association between anaemia and presence of vaginal candidiasis in non pregnant and pregnant women.

22 January 2021 5,965 3 View

Does GABA-B receptor upregulation alleviate chronic pain?

Novel compounds like fasoracetam have been proven to cause an upregulation in GABA-B receptors. While is it primarily used for cognitive enhancement in both healthy subjects and patients, does...

20 January 2021 2,220 4 View

Why the use of xylazine in veterinary field only not used to human?

Xylazine is an analogue of clonidine and an agonist at the α₂ class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle...

03 January 2021 9,746 9 View

TMAH effect on MgO?

Hello everyone, I use TMAH to remove AlOx (150nm) layer in liftoff processes. I would like to ask if TMAH has some influence on MgO barrier because I have 1.2 nm MgO barrier in my structure and I...

16 December 2020 297 1 View

Are calcium and magnesium necessary for good health?

Trace elements in human and disease.and particularly calcium and magnesium,its necessary to take magnesium with calcium , Magnesium is needed for calcium absorption. Because magnesium suppresses...

15 December 2020 8,383 4 View

How can I make water high in carbonate hardness for lab experiments?

I am trying to mimic the hardness of natural waters of Ohio streams and reservoirs. Ohio sediments are rich in limestone, so our surface water is unusually high in carbonate hardness and calcium,...

20 November 2020 5,738 4 View

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