Clinical Pharmacology

Clinical Pharmacology and Clinical Therapeutics | Review and cite CLINICAL PHARMACOLOGY protocol, troubleshooting and other methodology information | Contact experts in CLINICAL PHARMACOLOGY to get answers

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Questions related to Clinical Pharmacology

Can we use M9 media for AMES assay instead of the minimal glucose agar plates? will this effect the assay?

conventional AMES (MUTAGENECITY ASSAY) assay use vogel bonner salts, spizizens salts etc for prepration of the minimal glucose agsar plates. Is it ok to use M9 salts in this formulation instead of...

16 October 2018 6,840 0 View

Hi, which is the proper method for the inhibition of protein (albumin fraction) denaturation by plant extracts?

I am in doubt about different methods of preparations and calculations. While I performed it I got turbid material after denaturation by heating at 57 C for 3 minutes. So the absorbance at 416 nm...

01 September 2018 8,363 1 View

How can I calculate minimum effective conc. if I have dissociation constant ?

I have dissociation constant (Kd) for a drug- receptor complex. Can I calculate the minimum effective conc. (MEC) using this Kd? How also can I calculate the oral dose that will cause this MEC or Kd?

21 July 2018 854 3 View

What is a specific inhibitor for Grin3A subunit of mouse NMDA receptor?

We are studying the neurotoxicity of IFNa. As by informatics approach we predicted the Grin3A gene as the specific target for IFNa. Now we have shown that the intrcranial injection of IFNa...

12 June 2018 5,208 4 View

How much time does Flecainide take to reach its maximum "peak effect"?

Is it after reaching the steady state concentration (3-5days) or it may take more days to reach the maximum effect for atrial fibrillation control?

20 April 2018 1,312 11 View

Whats is your recommendation in treatment / relief of symptoms in lingua geographica?

I´m searching for experts opinions, advices about lingua geographica acute symptoms ( burning of tongue, pain...) treatment. We use local corticosteroids, desinficious rinses, magistraliter...

07 April 2018 4,019 3 View

How is the peak effect of Lisinopril is after 6 hrs?

Aren't we suppose to see the peak effect after 4-5 half lives of the drug? After reaching the Css? I did view the drug monograph, and it states that the peak effect is seen after 6 hrs not after...

06 April 2018 7,204 7 View

When disintegration test for conventional tablets is not required in case of good dissolution results?

For conventional tablet dosage form, what are the conditions in which disintegration results can be neglected in case of good dissolution results? please state the reference and link if possible

29 March 2018 1,987 6 View

I want to make a stable blood sample for a month ?

I want to make a stable blood sample. In my study, I want to make a comparative study of many hematology devices and I want to try many blood sample from different sources. I've seen many...

27 March 2018 2,690 9 View

Should percentages have Standard error of mean?

Hello, I conducted an antiemetic evaluation test on 4 local plants in chicks using the Copper Sulfate-induced chick emesis test. My question is, should the "% of inhibition of emesis" have...

15 March 2018 299 2 View

Could the consumption of myelin sheath components attenuate the multiple sclerosis?

The composition of myelin sheath is reported, it is rich in Lipids, Cholesterol, Cerebroside, Sulfatide, Ethanolamine, phosphatides, Lecithin, Sphingomyelin, Phosphatidylserine and...

04 March 2018 1,118 2 View

What are the main drawbacks of cancer immunotherapy?

Although cancer immunotherapy can be quite effective, it has a variety of drawbacks.

28 February 2018 6,977 19 View

Are Metronidazole/mebendazole contraindicated together?

It is recommended in some references to avoid the combination of metronidazole & mebendazole as the risk of steven johnson's syndrome is increased. 1-are there any statistics reg the...

28 February 2018 1,736 9 View

Nature news: Exosomes deliver ROS for regeneration. I wonder, Is that also true for cancer?

Inflammation and reactive oxygen species (ROS) production after central nervous system injury. What about the cancer? https://www.nature.com/articles/s41556-018-0048-9.pdf

26 February 2018 5,542 1 View

Acetaminophen or Aspirin or Ibuprofen for headache for someone who has NAFLD for occassional use ?

Which agent is the best for occasional use for someone who has NAFLD ? and why ?

23 February 2018 9,551 15 View

How do I confirm whether Tetrodotoxin citrate is working or not?

I have TTX citrate ordered from Hello Bio. On using it at 1uM as my working concentration, it didn't show any effect. How do I test whether the toxin is actually working or not?

17 February 2018 987 4 View

Is Enalapril safe for lactating women ?

There are contradictory data, two references are attached. What would be your decision ? Recommend it or not ?

17 February 2018 5,232 6 View

Isn't Css the same as the plasma therapeutic level ?

Isn't Css the same as the plasma therapeutic level ? Because if so, in the case of Acetaminophen, just one dose of 500 mg would reach the Css, and there would be no need for 4-5 half life ? if...

11 February 2018 3,944 4 View

This is confusing! Which drugs need to achieve steady state concentration in order to see the effect ?

Do all drugs need to achieve the steady state concentration after 4-5 half life in order to see the therapeutic effect ? Doesn't ibuprofen produce its effect from a single dose without 4-5 half...

07 February 2018 7,310 17 View

How does the MEC corresponds to minimum effective dose although they aren't the same ?

Take this example (Bisoprolol is the mentioned example ) : assuming that 5 mg is the minimum effective dose dosing with 5 to 20 mg, and mean peak values range from 16 ng/mL at 5 mg to 70 ng/mL...

07 February 2018 4,331 3 View

Which factor will decrease MORTALITY rate in COPD ?

a- Smoking cessation b- Long term supplemental Oxygen Therapy ( LTOT )

05 February 2018 4,955 4 View

Which guidelines/resource do you use to manage patients with cough in community pharmacy setting ?

I have researched, and there are many available ways to manage cough in community pharmacy setting, so which resource or reference do you use ?

28 January 2018 3,067 12 View

May someone point me to a resource to illustrate the difference between nasal congestion and rhinorrhea ?

I have researched, and they are used interchangeably, so I'd like to know if there is any paper or article that can illustrate the difference between both on the molecular or cellular level ?

25 January 2018 1,667 3 View

In practice, how do you know which pharmaceutical agent is more efficacious ? Is it just you go check graded dose response curve ?

Is it just you go check graded dose response curve for comparing different pharmaceutical agent ? Or there is another fast quick method ? Lets say you want to give the most available otc analgesic...

07 January 2018 5,482 9 View

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