The concentration-dependent inhibition of aminoglycosides and tetracyclines bring about bacteriostasis, however, aminoglycosides also have ability to directly create fissures in the outer membrane of gram-negative bacteria thus making the antibiotic bactericidal. Please the document link refers. https://www.aafp.org/afp/1998/1115/p1811.html
Dear Mohamed Nabil,
This could be useful for you:
"Protein synthesis is inhibited by aminoglycosides in at least three ways
(1) interference with the initiation complex of peptide formation; (2) misreading of mRNA, which causes incorporation of incorrect aminoacids into the peptide and results in a nonfunctional protein; and (3) breakup of polysomes into nonfunctional monosomes. These activities occur more or less simultaneously, and the overall effect is irreversible and leads to cell death."
You can look for more information in Basic Clinical Pharmacology, 15e by Bertram G. Katzung, Todd W. Vanderah.
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