I may have misunderstood your question, as the agent dissolved in DMSO may get frozen below 19 degree C (a freezing point for DMSO), but anyway, according to the manufacturer’s information ( https://www.selleck.co.jp/datasheet/carvedilol-S183102-DataSheet.html ), Carvedilol can be stored for 3 years at -20 degree C in powder and for 2 years at -80 degree C in solvent.