Is thymic neuroendocrine tumor pathologically and clinically malignant?

Given the recent case report by NEJM (Pallais JC, Fenves AZ, Lu MT, Glomski K. Case 18-2018: A 45-Year-Old Woman with Hypertension, Fatigue, and Altered Mental Status. N Engl J Med....

06 July 2018 1,597 1 View

Does the enhanced SA-beta-gal staining alone really reflect the cellular senescence?

I have recently wondered whether the enhanced SA-beta-gal staining alone really reflects the cellular senescence.

05 June 2018 1,495 0 View

How cancer undergoes "evolution"?

I think that cancer cells undergo "evolutionary dynamics" after chemotherapy and radiation therapy as the selective pressure. Excessive amount of reactive oxygen species (ROS) corresponds to one...

31 December 2017 996 1 View

What is the major pathohistological subtype of lung cancer due to the exposure to multi-walled carbon nanotubes (MWCNTs) in human ?

It has been reported that the animal experiments using rats have revealed the emergence of lung cancer, mainly bronchioalveolar carcinoma and combined carcinoma and adenoma after the exposure to...

31 December 2017 9,084 0 View

How to isolate only endothelial cells of blood vessels by flow cytometry?

When you isolate endothelial cells of the blood vessels, using only CD31 antibody is not enough to isolate them? Why alpha-smooth muscle actin (alpha-SMA) antibody is necessary according to some...

31 December 2017 2,527 2 View

How CD44 and Li-Fraumeni syndrome are related?

We have reported several years ago the 5-year-old male patient with Li-Fraumeni syndrome with osteosarcoma and atypical type of hepatic cancer. Intriguingly, the cancer stem cell marker CD44...

31 December 2017 4,808 2 View

Chemotherapy provokes the ectopic emergence of cancer stem cells in the tumor?

I have reported that chemotherapy for the patient with Li-Fraumeni syndrome results in the ectopic CD44 variant-positive cancer stem cells. Given that chemotherapy often increases the ROS level,...

31 December 2016 6,107 3 View

Denervation is effective for gastric cancer?

Neurotransmitters have been shown to drive tumor progression in the prostate glands and the stomach. In particular, it has recently been shown that acetylcholine promotes proliferation of...

31 December 2016 992 5 View

Do late-competent cancer cells correspond to cancer stem-like cells?

The investigators derived, from a human metastatic lung-cancer cell line and a breast-cancer cell line, latency-competent cells that seed distant sites after experimental tail-vein inoculation...

06 July 2016 8,088 0 View

Expression change in OPA1 and Drp1 is related to the mitochondria dynamics?

While Drp1 contributes to mitochondrial fission, OPA1 has been widely recognized as to promote mitochondrial fusion in cooperative manner with Mfn1/2. Several papers have shown the representative...

05 June 2016 7,579 2 View

Why does blocking with my immunogenic peptide cause nuclear fluorescence in ICC?

Hi all, I am validating a polyclonal antibody raised against human ANT4, through WB and ICC. In most of my controls, the antibody shows very little off-target binding, but when I pre-incubate the...

03 March 2021 5,999 3 View

What degree of missing data in a particular case/participant results in Expectation-Maximisation no longer working?

I'm dealing with a mediation model and am using the PROCESS module in SPSS. Due to SPSS and PROCESS being limited in the imputation methods - being unable to handle multiple imputation - the other...

02 March 2021 4,362 1 View

Have someone successfully used the ER alpha (Santa Cruz sc-8002) antibody in immunostaining ?

Santa Cruz now recommends this new antibody (F-10) but I can't find a publication using this reference. I'm working on human et non human primate hypothalamus and so far, it doesn't work. Is...

02 March 2021 10,003 2 View

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02 March 2021 3,060 3 View

Sample dilution for quantitative analysis using ELISA?

If the detection range is in ng/ml but the reference range is in ug/ml for a molecule or protein in serum or plasma .how to dilute and what is the initial volume to be taken for quantitative analysis

02 March 2021 7,670 3 View

Is there a powerful system for the security of the systems distributed on IoT systems?

Is there a powerful system for the security of the systems distributed on IoT systems?

02 March 2021 3,858 10 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Help request in CST microwave?

im working now on TPV solar cells and metamaterials and i realy need our help in CST microwave i have a tpv cell simulation and i want to extract particullarly the absorbtion of only the active...

02 March 2021 2,246 2 View

How Relativistic effects is one reason for lanthanide contraction?

The Lanthanide contraction which is the decrease in ionic radii of the elements in the lanthanide series from atomic number 57, lanthanum, to 71, lutetium, is due to poor shielding of the 4f...

01 March 2021 2,272 4 View

Issues with Permeabilization during Flow Cytometry?

Hello Everyone. Currently I am working to characterize macrophages in the myocardium after ischemia-reperfusion injury in rats. Due to the low total cell number isolated from rat hearts I can...

01 March 2021 3,867 3 View