01 January 2018 2 5K Report

We have reported several years ago the 5-year-old male patient with Li-Fraumeni syndrome with osteosarcoma and atypical type of hepatic cancer. Intriguingly, the cancer stem cell marker CD44 variant was ectopically induced after chemotherapy probably due to the selective pressure of excessive reactive oxygen species (ROS) provoked by chemotherapy.

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Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy

BMC Cancer2012;12:444

https://doi.org/10.1186/1471-2407-12-444

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