The investigators derived, from a human metastatic lung-cancer cell line and a breast-cancer cell line, latency-competent cells that seed distant sites after experimental tail-vein inoculation into immuno-compromised mice but that remain largely dormant for several months. These cells form tumors when injected into orthotopic sites but do not grow in the metastatic context.
I suspect that late-competent cancer cells correspond to cancer stem-like cells.
How do you think about it??
Article Defining Metastatic Cell Latency
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