Nearly all recent bibliography I consulted remains constant about ALV-A, B, C, D, J and K viruses being exogenous infective and ALV-E being an endogenous virus that is transmitted through genetic inheritance.
However, sometimes I find odd mentions in old papers (previous to 2000s) that mention ALV-E can infect cells or that it can recognize a certain receptor to enter the cell. Example: this paper mentions it with references in the introduction.
https://journals.asm.org/doi/abs/10.1128/JVI.01627-17?casa_token=WBn85V1vrWkAAAAA:MHp1Tg_YCKu_vGYq2-dY-XGrv4TSMbmT7bHaAbh8C4mdn162RTd41bgRMw5DiV5bnsH85zv4bCsN
The only idea I have that may explain this is that ALV-E virions may actually be infective but because there is a big number of proviruses in each chicken cell (5-35 complete insertions), chicken are immune to it thanks to ERV-derived immunity.
Could anyone explain this to me?
- Badges
- Science method