Clinical Chemistry

Clinical chemistry (chemical pathology and clinical biochemistry) is the area of clinical pathology that is generally concerned with analysis of... | Contact experts in Clinical Chemistry to get answers

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Questions related to Clinical Chemistry

The propaganda of table sugar (sucrose) could causes and feeds cancer cannot be real?

This because table sugar is extracted naturally from sugar cane or sugar beets and hydrolyzed to glucose and fructose and never could reach the body cells in its origin form. The hydrolysis...

09 September 2019 6,111 7 View

Where could I find some SOPs and formulations for making in house Clinical chemistry reagents?

Hi, I am looking for some resources to be able to find some SOPs and formulations for making in house Clinical enzymatic chemistry reagents like; Triglyceride, HDL-Cholestrol, Oxalate, Lactate,...

26 July 2019 838 2 View

Does anyone know of a suitable clinical chemistry analyser?

We currently use the Roche COBAS c111 system for ex vivo analysis and (sorry if you’re from Roche) it’s a bit rubbish. It only holds 8 samples at any one time and does not export to a network...

23 July 2019 5,061 5 View

Where could I find some SOPs and formulations for making in house Clinical chemistry reagents?

Hi, I am looking for some resources to be able to find some SOPs and formulations for making in house Clinical enzymatic chemistry reagents like; Triglyceride, HDL-Cholestrol, Oxalate, Lactate,...

07 July 2019 1,221 2 View

Does anyone know of a suitable clinical chemistry analyser?

We currently use the Roche COBAS c111 system for ex vivo analysis and (sorry if you’re from Roche) it’s a bit rubbish. It only holds 8 samples at any one time and does not export to a network...

07 July 2019 2,527 6 View

How to convert a methyl group (-CH3) to a carboxyl or amine group (-COOH/NH2)?

Which mechanism(s) or linker are needed to change a methyl group (-CH3) to a carboxyl or amine groups (-COOH/_NH2)?

02 February 2019 7,999 10 View

Validation in clinical (bio)chemistry ?

Can anyone explain me how to do Validation in Clinical Chemistry(biochemistry) and how calculate results ? Especially Recovery Thank you so much

06 June 2018 1,193 0 View

Looking for a postdoctoral position in Clinical Biochemistry?

I am Assistant Professor of Clinical Chemistry and Biochemistry, Finished my Ph.D. in Clinical Biochemistry, and Laboratory Biomedicine after working on "some novel Biomarkers for Acute Kidney...

10 October 2017 6,922 2 View

How to calculate free 25(OH)vitamin D?

Hi Can someone please advise on calculating free 25(OH)D using the Bikle formula. I have 25D in nmol/l, albumin in g/l and DBP in micromole/l. The numbers we come out with seem non-sensical but...

05 May 2017 1,088 0 View

What is the ideal method for measuring mouse HbA1C?

Hello, I'm currently working in a lab that routinely assesses the metabolic profile of obese/diabetic-like mice. When measuring HbA1C in the past, we used a manual boronate affinity column...

19 April 2017 1,493 3 View

What is the ideal method for measuring mouse HbA1C?

Hello, I'm currently working in a lab that routinely assesses the metabolic profile of obese/diabetic-like mice. When measuring HbA1C in the past, we used a manual boronate affinity column...

04 April 2017 8,723 4 View

Many tables shows the normal ranges but no one declare the Methods used. Wich are the Reference Methods for Camel's serum measuraments?

Chemical Chemistry Labs are using different methods (for example DGKC or IFCC) in order to detect the substance concentration in serum samples. Some methods are correlable and the Clinical...

02 February 2017 3,271 0 View

What are the equations that prove reducing the radius of the microspot would lead to increase in the sensitivity of the microarray?

In an article (Ligand assays: from electrophoresis to miniaturized microarrays, Roger P. Ekins, Clinical Chemistry 44:9, 2015–2030 (1998)), it is stated that smaller radius of a microspot leads to...

12 December 2016 2,482 0 View

Isopropyl alcohol for deproteinization prior to RPLC analyis?

Hi everyone. I'm trying to implement a new analytical method based on treatment biological samples (plasma, serum and urine) prior to analysis by RPLC (ODS column) in order to quantify...

12 December 2016 5,748 4 View

How to calculate sample size while establishing Reference Values in Clinical Chemistry?

Establishment of Reference Values is a very important aspect of Diagnostic Research. I want to know the minimum sample size required when data is parametric or non-parametric. In Teitz Text of...

25 October 2016 1,785 9 View

How to calculate sample size while establishing Reference Values in Clinical Chemistry?

Establishment of Reference Values is a very important aspect of Diagnostic Research. I want to know the minimum sample size required when data is parametric or non-parametric. In Teitz Text of...

10 October 2016 9,006 8 View

Can I use DNA from FFPE samples for Targeted Amplicon Sequencing?

I'm looking into using DNA from FFPE samples for targeted Amplicon sequencing to look at one gene in particular, has anyone tried this or know of something similar? I know the Illumina kits exist...

25 August 2016 6,073 3 View

Can I use DNA from FFPE samples for Targeted Amplicon Sequencing?

I'm looking into using DNA from FFPE samples for targeted Amplicon sequencing to look at one gene in particular, has anyone tried this or know of something similar? I know the Illumina kits exist...

08 August 2016 4,337 3 View

Can anyone suggest protocols for Polyethylene Glycol (PEG) or Triethylene Glycol (TEG) linking between two oligonucleotide strand ?

I want link two single DNA strand by PEG or TEG units. Can someone suggest any feasible protocols. Thanks very much.

24 July 2016 2,614 3 View

Any particular information on the link between blood type and mineral deficiencies ?

Interested to find if any links between blood type and mineral deficiencies

07 July 2016 6,043 5 View

Clinical Chemistry book?

Hi everybody, I'm looking for a book of clinical chemistry, I ask it here because I hope that someone can recommend me a complete good book that should be not only a manual for students! has...

07 July 2016 3,831 2 View

Has anyone successfully measured Vitamin D levels in follicular fluid using the ADVIA Centaur Vitamin D Total Assay kit?

My samples have been centrifuged to appropriately remove blood cells and granulosa cells, but I am worried perhaps the samples will not fall within the kits assay range (4.2 - 150 ng/mL).

07 July 2016 1,387 1 View

Can anyone suggest protocols for Polyethylene Glycol (PEG) or Triethylene Glycol (TEG) linking between two oligonucleotide strand ?

I want link two single DNA strand by PEG or TEG units. Can someone suggest any feasible protocols. Thanks very much.

07 July 2016 3,640 4 View

What is Inside of elisa coatable 96 plates that cause antibodis atach to wells?

06 June 2016 950 1 View

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