This research question explores the complex interactions between oral microbes and oral mucosal immune regulation. The diversity and function of oral microbes have important impacts on oral health and disease development. The microbial community is closely intertwined with the oral mucosal immune system through its metabolites, toxins, and interactions with the host mucosal surface.
As the body's front-line defense, the oral mucosa has two major immune systems, innate immunity and adaptive immunity, which can recognize and respond to microbial invasion in the oral cavity. Microbes may cause the occurrence and progression of oral inflammatory diseases such as gingivitis and periodontal disease by activating immune cells, inducing inflammatory responses, or interfering with host immune regulatory mechanisms.
A deeper understanding of this complex interaction between oral microbes and oral mucosal immune regulation will not only help reveal the maintenance mechanism of oral health, but also provide a theoretical basis for the development of new oral disease treatment strategies. Through advanced molecular biology techniques and bioinformatics analysis, the dynamic changes of microbial communities and their interactions with host immunity can be further explored, providing new perspectives and strategies for the development of personalized oral medicine in the future.
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