I am looking for SNPs found in Breast cancer related genes BRCA1/2 and connected to specific ethnic group. Can any one help me?

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Maulik Rachh

Dear Mona,

Normal Breast Cancer SNPs

BRCA1 gene SNPs

rs1799950 (Q356R)

rs4986850 (D693N)

rs2227945 (S1140G)

rs16942 (K1183R)

rs1799966 (S1613G)

BRCA2 gene SNPs

rs766173 (N289H)

rs144848 (N372H)

rs4987117 (T1915M)

rs1799954 (R2034C)

rs11571746 (S2835P)

rs11571747 (E2856A)

rs4987047 (I2944F)

rs11571833 (K3326stop)

rs1801426 (I3412V)

Please find attached files for more details on BRCA1/2 SNPs and its relation with cancer groups.

http://pelagiaresearchlibrary.com/advances-in-applied-science/vol5-iss2/AASR-2014-5-2-262-267.pdf

http://www.ncbi.nlm.nih.gov/pubmed/23886119

http://www.ncbi.nlm.nih.gov/pubmed/21890493

Navonil De Sarkar

Answer is already there. You can always check for those SNPs in 1000 genomes, HGDP or HapMap population data set. These are partially or fully available in public portal. One strategy may be, you can populate your SNP list SNPs from dbSNP common and clinically relevant SNP lists and check for population wise SNP frequency structure or allelic forms in the said data set. Hope this would work for you.

Per Olaf Ekstrøm

Try http://www.snpedia.com, search for Brca 1 or 2. That will give many SNPs rs numbers.