Hello everyone,
we extracted SNPs from dbSNP then we retrived the protien sequance from Uniprot. Then we submitted the amino acids changes corresponding to the protien change to proiect HOPE inorder to get the structure of the protien. Surprisingly we didnt find the amino acid correspoding to the excat position. E.g we have T592M and we found that in the positin theres isnt a T but an A.
We would like to know what could be the probelm or maybe the mistake? Knowing that we have the correct sequance from the Uniprot.
Maybe the following papers will help you:
1. http://mordred.bioc.cam.ac.uk/~sdm/sdm.php
2. http://folding.biofold.org/i-mutant/i-mutant2.0.html
3. http://foldx.crg.es/
4. http://www.hsls.pitt.edu/obrc/index.php?page=URL1258139151
5. http://www.ncbi.nlm.nih.gov/pubmed/?term=huyton+BRCA1
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