what are the top 3 challenges to the advancement of the field of Radiogenomics in cancer research? is it the availability of easily available low-cost matched imaging and biosamples with clinical history?
Radiogenomics top challenges are: the non availability of sophisticated imaging technologies and no enough research on genomics to investigate quite enough gene in question, as cancer rated genes are heterogeneous.
I'm try use a simple way with a gaussView, Trying to evaluate codon by codon. And comparing the healthy gene. But thank you, deeper analysis of the gene is still very rudimentary.
Hello Vishal Kampani
The challenges in the field of radiogenomics in cancer research.
1. The most serious challenge is tumor heterogeneity. From the biological perspective, radiogenomic studies rely on information derived from a biopsy. Biopsies suffer from a bias where it is assumed that the sample reflects the entire tumor burden. The samples are often obtained from only a portion of a heterogeneous lesion and cannot completely represent the whole lesion.
2. Because of the complexity of gene expression and signaling pathways, there are chances of introducing bias when one tries to directly link imaging features with genomic data.
3. There could be differences in acquisition parameters during image acquisition and reconstruction which could lead to variation in results. Also, the need for multi disciplinarity. The groups that are more clinically oriented will tend to look at problems from a clinical perspective, often at the sacrifice of the methodology. The technical group, on the other hand, will often tend to be driven by the development of novel methodologies, while the clinical relevance for this group would be of secondary importance. Better inter-disciplinary collaboration will help technically novel research to have a greater clinical impact.
Best.
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