I am working on the effect of fenofibrate on the 4T1 breast cancer metastasis by using Balb/c mice as the animal model ... but I have a problem in how I could give the required dose of fenofibrate without harming mice since most fenofibrate solvents will be toxic to them ... and the main problem is the limited solubility of fenofibrate in its various solvents like (DMSO, DMF and ethanol), so that to reach the required dose of the fenofibrate ( 0.2 % Wt/Wt), we will need a high volume of the solvent in which it will exceed the lethal dose .. also if we dilute the solvent we will need to inject mice with a higher volume that will exceed the intraperitonial volume dose ... SO I would like to ask kindly : 1 _ how we can give the required fenofibrate dose to mice without affecting them by the solvent ??? 2_ if we want to give the drug by food how we can avoid the variation in the amount of food intake daily by mice ??? Your time to answer my question will be appreciated ^_^ Montaser Haddad
Your time to answer my question is really appreciated ^_^
How about trying an oral gavage of suspension using a blunt L type gavage needle?
- Badges
- Science topic
- Similar topics
- Medicine
- Disease
- Disease Models
- Animal Models
- Rodent Models
- Mouse Models