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Questions related to Pharmacology
Vx2 cell morphology in 2D in vitro culture condition. What is the normal morphology of VX2 in this case? There are papers suggesting the maintenance of VX2 in vivo in rabbit, however, what is the...
09 September 2014 6,208 1 View
I used the following compounds in my experiments, but I was unable to find any information about their cell permeability. However, without this information, it can be difficult to understand the...
09 September 2014 9,013 6 View
I do not have experience on MEA (multi electrode array ) and I am looking for an in vitro slice assay being able to document pharmacological activities of PAM acting on the alpha-7 nicotinic ACh...
09 September 2014 870 3 View
09 September 2014 3,612 6 View
I am trying to dissolve API of Acetaminophen in Saline/Water to induced Hepatotoxicity in Mice/Rats. But it not dissolved. PCM is soluble in Ethanol and DMSO. May I use Ethanol/DMSO to dissolve...
08 August 2014 4,540 21 View
Hi, I am going to investigate on my research drug regarding influence on neurotransmitter. Kindly give your valuable suggestions regarding ideal biological sample like brain homogenate or serum or...
08 August 2014 9,569 7 View
08 August 2014 6,714 22 View
What are the ethics for the use of human physiological liquids after performing the requested analysis, in other words if some patients perform routine analysis of blood, urine, seminal liquid...
01 August 2014 1,222 4 View
Calcium Carbonate preparations create calcium oxalate which stores in the kidney and in long run causes the stone formation in kidney. Potassium citrate is used to treat/reduce the oxalate...
10 July 2014 1,407 4 View
Nigella sativa
07 July 2014 3,000 3 View
I had prepared an extract to be given to 3 group of rats. After conducted toxicity test, the extract showed no mortality up to 2000mg/kg. I would like to choose three doses to test for anxiolytic...
07 July 2014 3,205 16 View
Pharmacological, not siRNA or others.
07 July 2014 6,704 2 View
How does excess food increase lipid profile? Can increased lipid profile cause lipid peroxidation (forming reactive oxygen species)? If yes, then would it be good to add anti-oxidant in a diet?
17 June 2014 3,204 3 View
Animal experimentation is being done to prove the effectiveness of various substances used as medicine of different systems. Other than toxicological studies, it is seen that the study conducted...
06 June 2014 6,833 15 View
As observed and known, atorvastatin, a second generation lipid lowering agent causes myalgia which is seen in lesser extent and in lesser severity with rosuvastatin therapy. Furthermore,...
06 June 2014 9,550 26 View
Like the Chloropromazine dose-equivalent for anti-psychotics?
06 June 2014 8,019 3 View
06 June 2014 4,622 3 View
In general sense, all the drugs have an expiry date (shelf life). After the expiry date the drug is recommended not to use as it may produce toxic effects in biological system and/or lose its...
06 June 2014 3,573 4 View
Meropenem
06 June 2014 9,476 3 View
Proscar is used mainly in male patients with BPH.
06 June 2014 8,606 1 View
What are pharmacologic or rehab options in the case of a 33 year old man with lower body (toes to abdomen) TM and small encapsulated lesions on the spinal cord? It is 24 weeks since onset. The...
06 June 2014 3,781 3 View
The drug release for the film sample was calculated and matched to release from the total film, in this case, is it valid for research purposes to accept an extrapolated value for cumulative release?
19 May 2014 4,343 5 View
Data is contradictory
05 May 2014 7,004 4 View
05 May 2014 8,350 5 View