Pharmacology is the branch of medicine and biology concerned with the study of drug action. | Contact experts in Pharmacology to get answers
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Questions related to Pharmacology
Hey guys, I have been working with breast cancer biomarkers HER2, ER, and PR. I have tried to look up charges for those proteins. Just wondering if anyone knows if HER2, ER or PR are positively...
18 June 2018 9,000 3 View
I have worked on invivo toxicity of liver n kidney, now i m shifting towards invitro toxicity of mamallian cancer cell(breast cancer). I just wanted to know how to standralize the protocols i...
01 June 2018 1,059 3 View
Would 2 biosimilars, that have separately demonstrated interchangeability with the reference product, through adequate clinical designs (phase III trials with 2 arms, and at least three changes...
24 May 2018 8,786 3 View
There is a multivitamin capsule I'm working on that ended up being too big, I'm thinking of changing the excipients as a way to make the capsule smaller and more convenient to take. the capsule...
14 May 2018 7,224 8 View
Do cell-attached (CA) recordings sufficient for confirmation? I recorded in CA mode with K-gluconate intracellular solution (as after I needed to record firing patterns) without adding any...
30 April 2018 4,585 6 View
Ammonium Acetate Method is the widely used method for CEC determination. However, It is not working well with Andosols. Could you please recommend me an optional method? Thanks,
11 April 2018 6,101 0 View
Although we can measure serotonin in peripheral blood, it may not reflect its activity in the central nervous system. Pupil dilation may serve as a marker for noradrenaline changes, but I can't...
23 March 2018 9,430 3 View
Hello everyone! I'm looking for some papers that shows clearly some mechanical properties of human native myocardium, such as elastic modulus, ultimate tensile strength and the ultimate tensile...
09 March 2018 6,459 5 View
Hi all, In the past I have used a lysis buffer for bacterial RNA/DNA extraction that contained Guanidine Hydrochloride, N-lauryl sarcosine and LDS. I used it with spin columns. I can't find the...
05 March 2018 5,842 1 View
Discoloration of demineralized or cavitated surface of tooth is a major drawback of SDF (Silver Diamine Fluoride). This agent permanently blackens carious enamel and dentinal lesions. Since, it...
23 February 2018 4,708 4 View
Hi, I am interested in nucleotide metabolism and performed serial dilution and spotting using ade1 and ade2 knockout yeast strains. it seems like ade1 grows slower than ade2 eventhough they are...
20 February 2018 5,253 2 View
I have a limited background in chemistry and need to synthesize particles that have functional EDA groups populated on the outer shell.
08 February 2018 9,580 2 View
Hello all, I am trying to understand more about metastatic breast cancer. I understand HER2, PR or ER will be over expressed in CTC (based on different types of breast cancer). But I would like...
06 February 2018 814 2 View
A synthetic compound has a impressive ER-alpha binding affinity, comparable to the clinical standard but feeble anti-proliferation activity on breast cancer cells line. What are the possible...
28 January 2018 4,995 2 View
How it is impact on Pharmacological activity of concern plant?
27 January 2018 6,037 6 View
I am using liquid dichloromethane but in a few minutes its color is yellow
15 January 2018 9,706 4 View
Does anyone know of online resources which provide a comprehensive list of all genes associated with Alzhemer's disease? Thanks!
09 January 2018 6,201 4 View
according to available literature, PEO films/tablets have been used for controlled drug releasing system. can i use PEO as fast drug releasing oral drug delivery system through electrospun...
02 January 2018 1,947 1 View
I need to calculate the ic25 value. I have already the ic50 value by mtt assay but the concentration is so strong (it killed everything) and I need to reduce the treatment
29 November 2017 7,169 3 View
UPDATE: We made a STATA do-file - see below... Anyone who has the computation of blood pressure percentiles (z-scores) based on the CDC growth charts and the equation given in The Fourth Report...
06 October 2017 5,678 12 View
Hello, anybody knows how could has a demethylase a target gene if is able to demethylate all histone of one type? ex. KDM6B induce RAS_RAF pathway
28 September 2017 372 2 View
Hello, One of my supervisors has run metabolomic analysis on mouse faecal samples for me. Metabolites have been quantified and I have run statistical tests to see which differ between...
27 September 2017 9,673 4 View
I have a topical liposome and I am going to put this liposome in a cream , which this cream base wont break down my liposome , and my liposome stay for a long time at 4 degree . Some research...
14 September 2017 950 4 View
In dissolution study of buccal tablets, How to select dissolution fluid and their volume if drug's formulation is not official in pharmacopoeia.
27 July 2017 4,673 2 View