Pharmacology is the branch of medicine and biology concerned with the study of drug action. | Contact experts in Pharmacology to get answers
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Questions related to Pharmacology
Is it possible that vemurafenib can worsen cognitive behaviour in a melanoma patient on treatment with vemurafenib?
01 October 2015 1,166 0 View
There are many types of phosphodiesterase (PDE) as well as subfamilies of each type. What assay that we can do to identify the specific target of the drug using in vitro and in vivo study?
23 September 2015 4,146 3 View
I have been trying to dilute Cisplatin in 0.9% PBS, but when ever I dilute it instead of completely getting diluted the tube resides some yellow colored minute powdered particles, they get...
30 July 2015 2,986 3 View
I'm working in the role of benzo-[a]-pyrene in breast cancer? I would like to know the most toxic metabolite of benzo-[a]-pyrene in the body. Do its amount is same with the other metabolites?
08 June 2015 6,456 2 View
I want to calculate IC50 for MTT data by graghpad. I have two type of MTT data. First, 28 data point and second, 18 data point. In order to analyze in graghpad, I select analyze → XY analyses →...
12 April 2015 7,450 2 View
I am interested to know about distribution of various drugs (especially for cancer) between blood and interstitial fluid after injunction, and their clearance time from bloodstream. Please...
18 March 2015 2,536 4 View
My question does not just refer to their commercial use but also the R&D one… Let’s say I want to submit a Horizon 2020 project for a nano-functionalized cosmetic crème (not a medical grade...
18 December 2014 9,333 7 View
I have some doubt regarding fixing limitation of release specification and end of life specification for finished dosage forms in pharma industry. What basis the criteria is fixed. Help me in this...
05 December 2014 2,736 2 View
I am writing my research proposal about the MIS treatment on breast cancer.
01 December 2014 3,519 1 View
Hello everyone, I want to inject the mice with an inhibitor dissolved in DMSO. Does anyone have experience on how much DMSO is tolerable. Which volume range will not cause too much toxicity? Thank...
01 December 2014 4,951 5 View
any one know cyclin E inhibitor (Synthetic) . CDK2 inhibiotrs are there but i need cyclin E specific inhibitor.
27 November 2014 5,709 3 View
Most of the researchers are wonder about the dual activity of the curcumin.How it is possible for a compound to act as antioxidant(in normal cells) and ROS producer(in cancer cells)?
19 November 2014 8,057 17 View
This question is related to HIV drug class called fusion inhibitors. There is only one Fusion inhibitor called T20 (Enfuvirtide) approved by the FDA. I couldn't find the exact reason why the Roch...
13 November 2014 3,463 3 View
I was wondering if there was any association between phenylketonuria (PKU) and stuttering. I have tried searching the literature, but unfortunately couldn't find much at all (other a paragraph...
12 November 2014 3,173 5 View
I want the detailed information and pharmacology of how a statin causing Insulin Resistance as well as risk of new onset of T2DM. Recent studies shows that Atorvastatin causes Insulin resistance...
09 November 2014 2,542 5 View
This is a pharmacology subject where we collect some data analysis and we plot them on a graph to see the dose response curve. There is a file attachment where we add results There this image...
22 October 2014 8,099 12 View
Almitrine-Raubasine combination effectively increases both arterial oxygen partial pressure and it is known as effective O2 supplier. However, what is the actual mechanism of these two components...
21 October 2014 9,637 2 View
Such as acetylcholine chloride, trifluridine and so on. Does anyone have a good link for searching about this topic? Please can you give me this link? thanks a lot
16 October 2014 9,006 7 View
10 October 2014 3,709 7 View
I want to test the IC50 of a substance on a micro-organism using the range 2.5-200ug/ml. I was wondering if there is a standard increment I should test the substance at? For examples could I just...
10 October 2014 5,171 10 View
Using a pharmacological approach, I will like that you help suggest ways by which I can inhibit D-lactate production from the astrocytes in the brain?
26 September 2014 1,281 2 View
Is it linked to vasoconstriction? What are the consequences?
19 September 2014 4,245 12 View
Why is a natural medicine perceived to be of benefit only after its active ingredient is isolated, patented and turned into a pharmaceutical? Obviously $$$ has much to account for this phenomena...
09 September 2014 9,309 4 View
09 September 2014 7,304 11 View