How to select dissolution sample solution in dissolution tests?

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Bruce Neagle

So! Usually the samples are diluted with HPLC mobile phase so they are matrix matched.

Christian Fernandes

Dear Vipul Patel,

the sample from the dissolution vessel should be diluted or not . It depends on the working concentration of the method used to quantify.

Ahmed Agiba

As Christian said, it depends on the method of analysis.

Vipul,

Remember, dissolution is part of method development which is a process. As a generic manufacturer you have to prove your drug product is equivalent to the originator but that does not limit your method development options. Otherwise, we would be still using long C2 HPLC columns and 'buggy whips'!