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Questions related to Dosing
I isolated a novel compoud from bioactive extract. I need to know the most appropriate dose range for the invivo bioassay.
14 September 2020 824 6 View
Does plot of chemical toxicity (Y-axis) and its relation to dose (X-axis) is linear obeying LNT model or we have to apply Threshold model for doses response of chemicals. Information on any...
13 September 2020 5,289 5 View
I am working on an experimental SWRO plant with Ultrafiltration module. The Chemical Enhanced Backwash cycle for the UF membrane constitutes a biocidal flushing (NaOCl) followed by low pH HCl...
10 September 2020 8,211 3 View
In the infants to the adult age group, we have been given a concrete guideline for dose adjustment on the basis of CKD-Stages or creatinine clearance. this pathway is missing in neonates but...
08 September 2020 1,885 3 View
hi I want to use UV-C lamps for deactivate corona virus (covid-19) in my air condition system . With my researches , proper dose for deactivation of corona virus is about 47 j/m^2 (in average and...
08 September 2020 3,057 3 View
I got 5 conformations of ligands (from clustering histogram) in docking, which among the 5 should be taken for simulation....For eg; among the 5, the third and fourth poses appear entirely...
03 September 2020 1,256 4 View
Among the emerging decontamination technologies, low energy X-ray (LEXR) and low energy electron beam (LEEB) treatment are new trend to be an effective bacterial inactivation with a minimal...
02 September 2020 915 3 View
The following data are from a study of the effect of a specific mutagen on polychromatophilic erythrocytes. 9 vials of cells were haphazardly taken from a "master" cell culture. Each vial was...
02 September 2020 9,496 3 View
In an experiment with cardiomyocytes, each recorded cell was exposed to three different conditions. A) was a basal recording, B) was a low dose of a drug, and C) was a high dose of a drug. Every...
01 September 2020 3,350 1 View
Dear all, I would like to ask about dose for migration invasion assay compare to apoptosis dose. Why in some paper, they use the same dose for apoptosis and migration/invasion.? Which one is the...
27 August 2020 1,840 2 View
What is the equation according to which the experimental material is given to the laboratory animal according to its body weight by oral dosage
27 August 2020 5,342 3 View
I am trying to find a method that I can inject agomir/antagomir into SD rats, any method that does not involve a tail injection, which my reading showed as the widely used method. I need to...
26 August 2020 4,288 1 View
I have performed In-vivo study in rate model for new formulation as well as marketed formulation. Based on results new formulation have significant improvement in all PK parameters. Oral dose...
21 August 2020 2,361 1 View
How should a stock solution and work solution with tree pollens be prepared? Dear honored scientists, For an herbal extraction that contains multiple compositions (like different kinds of...
13 August 2020 8,750 7 View
Dear scientists, When should we have sham in mtt assay? What is the sham dose? How should we use its data for mtt assay analysis? I heard that if my drug solvent is PBS should take a dose of it...
13 August 2020 2,088 3 View
Let's consider two drugs, 'A' and 'B'. 'A' has a dose X and 'B' has a dose Y which give individual therapeutic activity. They are combined to produce Synergism to treat a particular disease. My...
10 August 2020 1,517 6 View
We are activating the expression of a gene by Cre mediated removal of a gene trap. Using a CreER driver we want to activate expression starting at E11.5. However after 1 injection with tamoxifen...
07 August 2020 6,251 1 View
I am working on simulating target compound removal from drinking water by PAC and I see a pattern in experiment results which shows that for higher initial concentrations of target compound...
05 August 2020 1,919 4 View
FLASH radiotherapy is an emerging treatment modality that uses ultrahigh-dose rates (above 40 Gy/s) to spare normal tissues and improve the therapeutic ratio compared with conventional...
03 August 2020 8,626 3 View
I am currently working on the development of inhalable nano-formulation. Is there an upper limit that can be administered through an inhalable route? and what are the invitro quality control tests...
03 August 2020 155 0 View
Is it possible to conduct an experiment without proper control where the effect of several doses of a particular nutrient on a particular crop will be evaluated? Is it possible to compare these...
02 August 2020 3,921 11 View
It is a known fact that Andrographis paniculata, is a annual herbaceous plant under the family Acanthaceae and commonly known as Chirata/Kalmegh, it was/is one of the most popular medicinal...
31 July 2020 9,822 5 View
DMBA dose, duration of exposure and route of administration
29 July 2020 5,179 3 View
Hi everyone, What is the rationale behind the administration of intracerebroventricular streptozotocin (ICV-STZ) in a dose of 3 mg/kg twice (day 1 and day 3) in rats to produce an animal model of...
26 July 2020 8,398 2 View