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Questions related to Dosing
the is because the preliminary result of superovulation with (400-560 mcg) stimufol among unflushed cows did not yield any embryos 10 cows each were treated with graded doses of stimufol (400,...
14 January 2021 3,831 2 View
there is a patient who has underwent a total igE test 1 month ago. can we rely on the results and determine omalizamab dosing? or the new test should be performed?
12 January 2021 409 2 View
I am working with Balb/c mice, and in my experiment, I have to inject mice with antigens, then get their spleen and collect the splenocytes for fusion. Recently, I get into trouble with the mouse...
05 January 2021 3,789 3 View
how we can calculated LOAEL and NOAEL for toxic pathological dose
03 January 2021 1,383 2 View
I need to formulate a water dispersible tablet with an a highly potent (Dose 7mg) API which is moisture, heat and light sensitive API with poor flow properties. Please advice on the formulation,...
02 January 2021 1,447 2 View
In case your answer is "yes," how would you represent them (in terms of weight) in the estimates? The hypothetical scenario is that I have 3 biological setups designed to test the same hypothesis...
31 December 2020 8,878 2 View
I 'm currently working on how EFM gives a trusty modulation in complex corrosion behavior. I can have a I usually get pretty good causality factor check under simple solution. While I starting...
23 December 2020 167 0 View
I am developing a Fixed Dose Combination dosage form, which have an active pharmaceutical ingredient in the coat and another one in an extended release core of tablet. During development, I have...
18 December 2020 3,417 2 View
Hello folks! We have synthesized pyrrhotite from pyrite in inert gas at 800 degrees for 4 hours. We analysed it via XRD (X-ray diffraction) and confirm the pyrrhotite phase. However, what is the...
17 December 2020 670 1 View
I would like to use CDM (continuum damage mechanics) for modeling damage in my constitutive model and I need to incorporate a variable (or its effects) into my mechanical damage that doesn't...
16 December 2020 7,454 2 View
Hi Dose any-one knows about cleaning validation protocols for pathogen-bacteria from fermentor? In industerial size, 1000 lit?
16 December 2020 4,571 3 View
In my psychotherapeutic practice I have a client who decided to use really small doses of muscimol regularly. He gains it from dried fruit bodies of Amanita muscaria. Although he is quite enjoying...
15 December 2020 6,181 2 View
I wanted to use CCD aur box-behnken design Which one is better and how I can do experiment using design expert software
14 December 2020 6,481 5 View
Trying to understand the relationship between t1/2 and dosing regimen (qd, bid, tid, ...). Are dosing frequencies for a drug approved based on t1/2 or other factor like AUC..etc? where can such...
14 December 2020 5,690 5 View
Dear Folks, We immunized mice with 7kd synthetic peptides. We could not get a very good anti-body titer in first booster dose (second time immunization). However, we got satisfactory antibody...
11 December 2020 5,790 12 View
Dose the metals oxides like (Fe3O4, ZnO TiO2) can coordinate with organic linker in the purpose of MOFs synthesis?
10 December 2020 5,040 2 View
Working in an FDG production lab for around 20 years. Does the annual ICRP dose limit of 20mSv/Year avegraged over 5 years (and in a single year upto 50mSv) is following the ALARA principle. Does...
08 December 2020 582 5 View
"Toxicological evaluations revealed that Cur is found to be pharmacologically safe, even up to 12 g per day, as reported by several animal studies and in phase-I clinical trials Similarly,...
08 December 2020 3,211 1 View
Is there any formula or equation to predict the corellation between in vitro and in vivo studies. How to calculate the dose in rats if IC50 value has been calculated for a compound in...
04 December 2020 7,397 4 View
Absorbed dose rate in air (or D) was obtained from the formula suggested by UNSCEAR (2000) which uses the activity concentration of U-238, Th-232 and K-40 (high purity germanium detector...
24 November 2020 2,706 3 View
Dose conversion from rat to mouse?
24 November 2020 2,027 3 View
What is XX% effective reported for the new vaccinates based on??? On clinical symptoms???, on increased antibody???, CTL???, NK??? production, or on some other trigger??? Perhaps efficacy is...
24 November 2020 5,112 3 View
We are administering mifepristone as a therapy for pup mice up to 21 days old, unfortunately due to that age normal vehicles this drug can dissolve in like EtOH and DMSO were found to be toxic. We...
24 November 2020 8,687 0 View
The drugs in question are mostly chronic maintenance drugs with PO, topical, ophthalmic and tube feeding route. What parameters determine dose intervals?
17 November 2020 10,075 3 View