48 Questions 103 Answers 0 Followers
Questions related from Vinod Kumar Gupta
Of course, it is called MIGRAINE.
03 March 2019 7,745 1 View
The nature of lacunar and non-lacunar brain infarcts continues to elude investigators busy in piling up data. Does all single infarction have lower risk of stroke recurre... This is not merely...
01 January 2019 7,466 6 View
Why scientists must share their failures Failure moves research forwards 4th May 2017 We don’t ask people in other professions to do it, but it’s vital for speeding up progress in crucial areas of...
01 January 2019 8,946 10 View
1. Lateralization of headache. 2. Blood-brain barrier. 3. Plasma glutamate cannot freely cross the BBB. 4. Plasma magnesium cannot freely cross the BBB. 5. Cortical spreading depression till...
12 December 2018 1,361 4 View
Such issues arise when we start thinking through technology, and, expect technology to do the hard work for us. Will technology oblige and make clinical medicine its appendage. Or will technology...
12 December 2018 5,491 19 View
Glutamate has attracted lot of attention in neuroscience and migraine research. It is time to come to grips with this issue.
11 November 2018 7,318 5 View
Obviously, it is NOT both.
10 October 2018 1,399 10 View
Would you participate as a ghost scientific author? What are the advantages and disadvantages from ghost authorship? How does it impact science and human welfare? What is the ethical aspect of...
10 October 2018 8,119 0 View
Is it related to the certitude or the uncertainty of the article? Or is there some sense to this nonsense?
09 September 2018 1,399 5 View
03 AUGUST 2018 NATURE Gigantic review of German science recommends more data and diversity Big data and diversity lacking at Germany’s biggest science organization.
08 August 2018 3,492 1 View
Are the waves already out there? Ready for capture?
05 May 2018 9,772 8 View
Does worrying help performance? Is worrying intrinsic to the human dimension? Do animals worry? How is worrying translated into brain physiological processes? Is worry equivalent to stress? Are we...
04 April 2018 4,487 4 View
How can the patient be kept primary? Is the patient less important than the research or the trial? Is trust in doctors declining? Are doctors being perceived as device-toting gadgeteers? Is...
04 April 2018 9,471 2 View
I have observed the mutual back-scratching reflex of Recommendations at RG. Recently, one member announced that he had 2000 recommendations. Others may have more. As I have asked earlier, is a...
04 April 2018 1,528 16 View
We have all experienced patients who emphatically declare vast knowledge of their ailments by spending time on the Internet. How do we manage such patients? Do they make or mar their own cases...
04 April 2018 5,661 8 View
Knowledge is both a pleasure to give and to receive. Its is rare human who does not accept mental horizon-widening knowledge with grace. How has artificial knowledge (AI) impacted this otherwise...
04 April 2018 9,749 2 View
IN his fascinating foreword to the autobiographical tome: The Barons 500: Leaders For The New Century, Copyright 2000 Barons Who's Who, ISSN 1059-5392, Editorial Director John L. Pellam, Irvine,...
04 April 2018 3,106 13 View
Scientists are not allowed to function as true leaders. Scientists are selectively killed by despots and rogue leaders. Do scientists have a tunnel vision that precludes them from such onerous...
03 March 2018 8,528 1 View
All of us at RG are educated and trained -- self-trained or under mentor-guidance. All of us hold degrees awarded by Universities worldwide. Are we all intellectuals? If yes, you need not read...
03 March 2018 3,594 3 View
Specialization is imperative. It is, however, impossible for the specialist to understand the human being as a whole. Medicine has artificially separated the sick human being into small segments,...
09 September 2017 1,783 2 View
Bias, the killer of all review, is the single most pernicious element of peer-review. What do you think? Posted in: Scientific Communitydoi:10.1126/science.aaq0322
09 September 2017 3,408 3 View
With the magic term "experimental", we have become prisoners of our own rhetoric. Given the direction in which we are being dragged by today's mega-trials, we better extricate ourselves before we...
09 September 2017 4,453 0 View
To most researchers, as has often seemed the case in medical literature --- the term biological stands for "laboratory, or genetic, or non-environmental or physiological or organic " -- modified...
08 August 2017 2,647 2 View
Science is an oversimplification or a simple explanation for a seemingly complex observed phenomenon--this is a universal definition applicable to all branches of science. Science is not a simple...
08 August 2017 5,361 2 View
Seven decades ago, the chance "discovery" of cortical spreading depression unleashed a storm of excitement amongst neuro-scientists, and, a spurt in animal experiments to replicate the findings...
08 August 2017 9,712 0 View
Despite medical advances, there is apparently little to cheer about the HIV epidemic (Lancet, 2017, August 12, 2017 --see attachment). . Contribution of the human towards their own medical...
08 August 2017 8,648 6 View
The term "pathology" evokes surprise among the cognoscenti, the expert community of researchers at tertiary headache centres worldwide, that fervently publishes papers about the nature and future...
08 August 2017 2,157 0 View
I would insist on a full expose on the rules and regulations that Ethical Committees of premiere MEDICAL INSTITUTIONS follow before sanctioning randomized controlled trials. (e.g., MIST TRIAL)....
08 August 2017 6,022 0 View
COUGH IS ONE OF THE MOST COMMON SYMPTOMS IN HUMANS. SOMETIMES COUGH IS ASSOCIATED WITH HEADACHE. SUCH COUGH HAS BEEN ASSUMED TO BE LINKED WITH BRAIN INFECTION ALSO. IN THE PAST, INVASIVE THERAPY...
08 August 2017 5,970 3 View
TO PREVENT MIGRAINE, ASSUMING THAT MIGRAINE ARISES FROM THE BRAIN OCCIPITAL CORTEX, EVERY EFFECTIVE PHARMACOLOGICAL AGENT MUST CROSS THE BLOOD BRAIN BARRIER FREELY OR READILY TO INFLUENCE BRAIN...
08 August 2017 4,811 3 View
STRESS IS THE COMMONEST KNOWN PRECIPITANT OF MIGRAINE. IT IS NOT COMMONLY SAID THAT THE TERM "STRESS" CARRIES NO USEFUL FUNCTION -- (BRUCE CHARLTON, EDITOR -- MEDICAL HYPOTHESES) AND SIMPLY...
08 August 2017 2,115 0 View
What is original in science? Is it the established myth or the dogma that cannot be challenged due to any reason including the absence of an alternative explanation -- hence surviving by...
08 August 2017 4,012 1 View
Sometimes, research can be misdirected, as it has been in primary vascular headache. The Tertiary Headache Centres, a group of totally dedicated and committed scientists, enforce their...
08 August 2017 6,010 0 View
WHATEVER ONE'S RELIGION, THE FIRST THING IS TO BE HUMBLE -- AS ONE CANNOT ONESELF CONTROL ONE'S OWN EXISTENCE -- BIRTH OR DEATH OR THE NUMBER OF HEARTBEATS OR BREATHS THAT HAVE BEEN GRANTED TO...
08 August 2017 7,422 2 View
THE DISCOVERY OF THE FUNDAMENTAL CAUSE OF MIGRAINE ATTACKS NEEDS RESOLUTION OF THIS MOST IMPORTANT QUESTION IN MIGRAINE PATHOPHYSIOLOGY. I WILL DETAIL THIS OUT AFTER CONSIDERING RESPONSES. THERE...
08 August 2017 1,562 0 View
With the publication of certain articles, migraine pathophysiology has advanced from the Dark Ages, and, evolved from a descriptive art to stand at the threshold of science (see...
08 August 2017 8,185 1 View
I received this letter today. It is death knell for fishing expeditions in medical science, including randomized clinical trials. If applied to headache research, practically nothing can be...
01 January 1970 759 0 View
We think, therefore, we are. I start this thread, to celebrate and never end, our quest as a thinking species. "There is the churning and the boiling of the sea, and the foam on top of it and...
01 January 1970 7,209 12 View
Peer reviewers are four times more likely to give a grant application an "excellent" or "outstanding" score rather than a "poor" or "good" one when they are chosen by the grant’s applicants, an...
01 January 1970 5,695 3 View
In a decision Thursday, a VA committee declined to cover the drug (ESKETAMINE) for all beneficiaries, instead restricting the nasal spray to patients who have not responded to other treatments and...
01 January 1970 6,649 1 View
No question is more important to elucidate the function of serotonin at the level of the brain. NEUROLOGY (AAN) turned down my exhaustive paper around 1995 without even an external review. The...
01 January 1970 5,668 0 View
If so, let us list them in order that future generations of scientists -- our descendents in time -- may address them better. Myths are not always easy to identify as they lie submerged under...
01 January 1970 2,996 0 View
By Ken Gordon STAT April 1, 2019Depth is Paging Dr. Topol: Grasping the multidimensional narrative of ‘Deep Medicine’ Depth is all about discovering a new dimension. When you add width to...
01 January 1970 8,969 8 View
This need was felt as way back as 1990-1992 by two leading researchers / scientists, one of whom was the then Chief-Editor for the journal Headache. As is very common in human endeavour, nobody...
01 January 1970 5,148 2 View
What using animals for scientific research taught me about myself By Justin Chen--a must read article. STAT When I looked for the deeper meaning of existence, I found that I was too skeptical...
01 January 1970 351 3 View
Meningeal contribution to migraine pain: a magnetic resonance angiography study Sabrina Khan Faisal Mohammad Amin Casper Emil Christensen Hashmat Ghanizada Samaira Younis Anne Christine Rye...
01 January 1970 3,954 0 View
Can raised intrathoracic pressure cause a right-to-left intracardiac shunt through the patent foramen ovale channel?
01 January 1970 3,968 3 View
The medical profession allows nutty trials, fooling the participants who are already over-stressed. This is nothing but a SHAME and a SCAM. I would not be surprised if there were to be a trial of...
01 January 1970 1,289 2 View
