• THE DISCOVERY OF THE FUNDAMENTAL CAUSE OF MIGRAINE ATTACKS NEEDS RESOLUTION OF THIS MOST IMPORTANT QUESTION IN MIGRAINE PATHOPHYSIOLOGY. 
• I WILL DETAIL THIS OUT AFTER CONSIDERING RESPONSES. THERE IS ALWAYS A PROPER TIME TO DISCLOSE SOMETHING THAT IS FASCINATINGLY AND IRRITATINGLY OR SUPPOSEDLY OR PURPORTEDLY OR SECULATIVELY NEW OR NOVEL OR A SIMPLE ACT OF SERENDIPITY (H. PYLORI DISCOVERY), RELATED TO COMPREHENSION OF THE GENERAL UNDERSTANDING AND PERCEPTION OF THE HERD -- THE HUGE COLLECTIVE GROUP OF INTELLECTUALS  AT RESEARCHGATE, AND, ITS PERCEPTION OF THE INTELLECTUAL BASIS OF SOMETHING ALL THINK THEY ALREADY KNOW FULLY ABOUT.
• I PERCEIVE A RESTLESSNESS AND RELUCTANCE AND RESISTANCE TO MY PROPOSED QUESTIONS. THE ANSWERING PART FROM THE READERS HAS NOT EVEN BEEN APPROACHED -- IT IS STILL LIGHT-YEARS AWAY.
• I HAVE STUDIED THE SAME QUESTIONS FOR NEARLY FIFTY YEARS TO GET WHERE I AM PRESENTLY. IF THERE WAS AN EASY OR READILY AVAILABLE ANSWER, I WOULD NOT NEED TO WRITE ANY FURTHER.
• ALL MY PUBLISHED ARTICLES HAVE ALREADY UNDERGONE VERY RIGOROUS AND OFTEN RANCOROUS REVIEW BY TOP-NOTCH ANONYMOUS NEUROLOGICAL AND NEURO-OPHTHALMOLOGICAL EXPERTS IN HIGH-IMPACT INTERNATIONAL JOURNALS THAT ARE RESPECTED BASTIONS OF KNOWLEDGE AT THE FRONTIERS OF THE KNOWN-UNKNOWN BORDERS OF OUR THINKING IN ADVANCED COUNTRIES ALL OVER THE WORLD, WHERE CUT-GRASS SHARP INTELLECT -- NOT TENURE OR PROFESSORSHIP OR FELLOWSHIP OR DEGREE(S) OR MERE EXPERIENCE OVER DECADES OR MERELY ATTENDING MEDICAL CONFERENCES AND POSING QUESTIONS/POSTERS/TALKS/TRIAL DATA FOR PUBLIC VIEW OR SELF-SATISFACTION OR ANY OTHER NARCISSISTIC MOTIVE THAT PRECLUDES CONTEMPLATION -- IS RESPECTED IN THE FIELD OF ADVANCED SCIENTIFIC RESEARCH. TO GET THE THIRD-EYE OF ESP (EXTRA-SENSORY PERCEPTION OR INSPIRATION -- THE UNDERSTANDING THAT CARRIES HUMANKIND FORWARD) THE GIVING AND TAKING OF RESPECT IS QUINTESSENTIAL RATHER THAN HOLDING THE INTELLECTUAL TO RIDICULE OR MOCKERY. SUSTAINED CONTEMPLATION IS ALWAYS PAINFUL TO THE HUMAN MIND.
• YOU ARE EITHER AN EXPERT IN THIS FIELD OR YOU ARE NOT. IF YOU ARE AN EXPERT, YOU VERY WELL KNOW THE HOW-WHEN-WHERE-WHAT-WHY-WHO (KIPLING'S SIX HONEST SERVING MEN) TO RESPOND. IF YOU ARE NOT AN EXPERT IN THIS FIELD, BUT STILL A WELL-TRAINED SCIENTIST OR MEDICAL PROFESSIONAL WITH RESPECT FOR THE KNOWLEDGE ALREADY IMPARTED TO YOU, YOU HAVE A GUT REACTION TO DISBELIEVE AND LAUGH-OUT-ALOUD BUT YOU STILL HAVE THE ABILITY AND THE OPPORTUNITY AND THE RESPONSIBILITY TO RESPOND APPROPRIATELY LIKE MATURE SCIENTISTS WHO ARE MEMBERS OF AN ELITE GROUP OF INTELLECTUALS (SOME 10 MILLION RESEARCHERS ARE REGISTERED WITH RESEARCHGATE WITH OVER A 100 MILLION PUBLICATIONS REGISTERED AT THIS RESPECTABLE WEBSITE, THAT GIVES A PORTAL FOR BUDDING NEW TALENT AND BURSTING NEW IDEAS IN LONG-FESTERING CUL-DE-SACS OF HUMAN THINKING).   
• MIGRAINE IS KNOWN SINCE ANTIQUITY, BEFORE HIPPOCRATES, BEFORE PRE-HISTORIC TIME, MAYBE AROUND 5-6 MILLENNIA. LIKE CANCER, MIGRAINE WILL ALWAYS AFFLICT AND HAUNT HUMANITY. THAT IS NOTHING TO MAKE FUN OF. I AM STILL WAITING FOR A SINGLE SERIOUS SCIENTIFIC RESPONSE OR COMMENT.
• MOST OF THE KNOWN EXPERTS ARE KEEPING THEIR FINGERS CROSSED AND HOPING THAT HURRICANE VINOD WILL PASS-BY AND LEAVE THEM AND THEIR THINKING INTACT. THOSE WHO HAVE NEVER PUBLISHED OR RARELY PUBLISHED-CASE-REPORTS-AT-RANDOM WITHOUT CONTEMPLATION OVER DECADES THINK THIS IS A FORM OF CIRCUS. WELL, IT CERTAINLY IS AN INVENTIVE CIRCUS WHERE ONLY SENSE AND SENSIBILITY COUNT -- NOT JEERING OR DERISION. 
• IN THE ABSENCE OF A SUSTAINED CULTURE OF RESEARCH IN DEVELOPING COUNTRIES AND REGIONS LIKE ASIA, SOUTH-EAST ASIA, THE MIDDLE-EAST, MOST OF AFRICA (THAT PRODUCES MARVELLOUS ATHLETES AND MARATHONERS), THE ABILITY TO THINK OUT-OF-THE-BOX IS RARELY PERCEIVED OR DEMONSTRATED AS NECESSARY.
• ALL MEDICAL ADVANCES ARE THE THE OUTCOME OF SUSTAINED THINKING -- NOT JUST OPENING OF THE MOUTH OR THE CLICKING THE MOUSE TO SPEAK-OUT-OF-TURN WITHOUT MUCH OR ANY DEGREE OF THINKING OR TO GIVE A RAPID-FIRE RESPONSE.
• MANY TIMES HISTORY UNFOLDS BEFORE OUR VERY EYES, BUT WE FAIL TO REGISTER ITS FUTURE IMPACT AS OUR UPPER-STOREY (BRAIN) CIRCUITS NEED FURTHER REFINEMENT. IT IS LIKE TASTING CHAMPAGNE OR CAVIAR OR OTHER DELIGHTS THAT FORCE YOU TO GO BEYOND THE DAILY COMMON HUMDRUM OF SIMPLE EXISTENCE OF PUSH-AND-SHOVE.
• AND THEN THERE IS FRAUD IN MEDICINE. DO YOU KNOW THAT MOST PUBLISHED STUDIES IN MEDICINE EMPLOYING ADVANCED STATISTICS ARE PARTIALLY OR INTRINSICALLY FALSIFIED OR ARE NOT LOGICAL OR ARE AT THE BEHEST OF POWERFUL PROMOTOR OR ADVOCACY GROUPS INCLUDING THE INDUSTRY AND THE GOVERNMENT. DO YOU KNOW THE FAULTS OF THE p-VALUE AND ABOUT THE FUTURE DECLINE OF THE SAME. 
• HOW CAN I HELP IT IF YOU ARE STILL A INNOCENT BABE-IN-THE-DEEP AND DARK WOODS OF THE SCIENCE OF MEDICINE?
• DO YOU THINK ANY NEUROPEPTIDE HAS ANY RELEVANCE TO MIGRAINE PATHOPHYSIOLOGY? NEUROPEPTIDES ARE MERE MESSENGERS OF THE NEURONS, AND, LIKE MOST HOSPITAL ADMINISTRATORS THEY DO NO HELPFUL WORK AT ALL.
• MIGRAINE HAS STILL NOT CRYSTALLISED AS A SCIENCE -- IT IS AN ART WITH ONLY VERY FEW PHENOTYPIC /GENOTYPIC POORLY UNDERSTOOD AND ELUCIDATED LAWS. 
• IF YOU FIND ALL THIS STRENUOUS AND SOMEWHAT GIBBERISH AND DEFINITELY BORING, MAYBE IT IS BEST TO PUT ON YOUR HAT AND SETTLE TO REST -- GO TO PASTURE OR THE WATER-HOLE AND DOZE OFF. AFTER ALL, REST IS INDEED IMPORTANT.
• NOTHING, AND I REPEAT, NOTHING WOULD GIVE ME GREATER PLEASURE IF YOU COULD PROVE THAT I AM WRONG OR FALSIFYING OR SULLYING THE ILLUSTRIOUS HISTORY OF SCIENCE, AND IN PARTICULAR MEDICAL SCIENCE.
• I AM ALSO AN EXPERT IN OCCULT PRE-MORTEM SARCOIDOSIS / NEUROSARCOIDOSIS / CHEST SARCOIDOSIS AND CAN PICK-UP THE DISORDER FROM AS FAR AS THE MOON. MIGHT MAKE YOU SIT UP, AT LEAST.
• I AM ALSO REGARDED AS ONE OF THE FINEST AMATEUR POETS IN THE ENGLISH LANGUAGE WORLWIDE. A DEGREE OF REFINEMENT IS ESSENTIAL TO MAKE A DISCOVERY IN SCIENCE -- JUST A DEGREE OR TWO.
• DID YOU ALSO KNOW THAT DATA ARE A TERMINAL OUTCOME OF ADVANCED HUMAN THINKING. YOU MAY BADLY NEED TO REST NOW.
• BUT, EN PASSANT, I SEND MY REGARDS TO ONE AND ALL, IF YOU HAVE INDEED MANAGED TO READ THIS FAR. AS A GIFT AT THIS LEVEL, I AM ALSO REGARDED AS ONE OF THE FINEST ETHICIST AGAINST RCT IN HUMANS AND SENSELESS ANIMAL EXPERIMENTATION. THIS IS ALL RECORDED IN THE AUTO-BIOGRAPHICAL RECORDS OF THE FINEST INSTITUTIONS IN U.K. AND U.S.A. SINCE 1996. I ALSO SHARE THE SAME PAGE AS BILL GATES (THE MICROSOFT BOY/MAN WONDER) IN ONE OF THE LEADING VOLUMES OF THE 21ST CENTURY (IRVINE, CALIFORNIA, U.S.A.). LIKE BILL, I DO NOT HAVE BLIND FAITH AND RESPECT FOR MERE FORMAL INSTITUTIONAL LEARNING. A TOP-NOTCH QUALIFIED PHYSICIAN IN 1980 WITH BACKGROUND OF AIIMS, NEW DELHI, INDIA, I REFUSED TO FURTHER SPECIALISE. LIKE BILL HAD THE MICROSOFT ALGORITHM WIRED INTO HIS MIND EARLY IN LIFE, THE ALGORITHM OF MIGRAINE WAS HARD-WIRED INTO MY MIND AS LONG BACK AS 1974 AS A 23-YEAR MEDICAL STUDENT.
• SHALL I FURTHER SPOIL YOUR DAY, YOUR WEEK, AND YOUR DECADE? I WAS ONCE ALSO CONSIDERED FOR NOMINATION TO THE NOBEL PEACE PRIZE BY VIRTUE OF MY CONTRIBUTION TO PEACE AND HARMONY IN THE WORLD.
• IN U.K. AUTOBIOGRAPHICAL CIRCLES, I AM REGARDED AS A LIVING LEGEND AND AS ONE OF THE FINEST INTELLECTUAL OF THE 21ST CENTURY.

THERE IS MUCH MORE...LET IT PASS. CHILDREN CAN ALWAYS GO OUT TO PLAY...

VINOD

PS. I JUST CAN'T RESIST WRITING THAT MY MAJOR CRITICAL REVIEW ON CSD WAS COMMISSIONED BY THE EDITOR OF THE JOURNAL OF NEUROSCIENCE ALMOST ONE YEAR AGO AND IS DUE SHORTLY FOR SUBMISSION AND THE CUSTOMARY REFEREEING PROCESS--A PROCESS THAT I REGARD PER SE  AS A SIGNIFICANT INTERNATIONAL HONOUR.